Sex-Specific Associations Between Leucocyte Measures and Obstructive Sleep Apnea in Han Chinese.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S475717

Taomei Li, Lu Tan, Fei Lei, Xiangdong Tang

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Abstract

Background: White blood cell (WBC) and its subset counts are standard, inexpensive, direct markers of inflammation. Obstructive sleep apnea (OSA) is implicated in changes in inflammation markers, and sex differences are evident in both OSA and inflammation. It is unknown whether sex modulates the relationship between OSA severity and leukocyte measures.

Methods: 1222 patients (914 males, 308 females) underwent overnight laboratorial polysomnography and measurement of WBC and its subset (lymphocyte, neutrophil, monocyte) counts. Patients were divided into primary snoring and mild, moderate, and severe OSA groups, and differences in leukocyte parameters were analyzed separately by sex in multivariable analyses.

Results: In multiple regression models, higher apnea-hypopnea index (AHI) was independently associated with neutrophil counts only in men, and with higher total WBC, lymphocyte and monocyte counts both in women and men. Further ordinal logistic regression analysis revealed a significant association between AHI and total WBC (OR 1.87, 95% CI 1.09-3.23) and neutrophil (OR 1.77, 95% CI 1.02-3.07) counts in men only. Correlation analysis also revealed more robust relationships between leukocyte measures and cardiometabolic risk markers in men than in women.

Conclusion: This study provides novel data suggesting a significant association between neutrophil count and OSA severity only in men but not women. Similarly, the relationship between leukocyte parameters and cardiometabolic risk markers were more pronounced in men than women. Our findings suggest a sex-specific impact of OSA on leukocyte measures and on their relationship with indices of cardiometabolic risk.

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汉族人白细胞指标与阻塞性睡眠呼吸暂停之间的性别特异性关系

背景：白细胞（WBC）及其亚群计数是标准、廉价、直接的炎症指标。阻塞性睡眠呼吸暂停（OSA）与炎症指标的变化有关，OSA和炎症的性别差异也很明显。方法：1222 名患者（914 名男性，308 名女性）接受了夜间实验室多导睡眠图检查和白细胞及其亚群（淋巴细胞、中性粒细胞、单核细胞）计数测量。患者被分为原发性打鼾组和轻度、中度和重度 OSA 组，在多变量分析中按性别分别分析了白细胞参数的差异：在多元回归模型中，只有男性的呼吸暂停-低通气指数（AHI）较高与中性粒细胞计数独立相关，而女性和男性的白细胞总数、淋巴细胞和单核细胞计数均较高。进一步的序数逻辑回归分析显示，只有男性的 AHI 与白细胞总数（OR 1.87，95% CI 1.09-3.23）和中性粒细胞（OR 1.77，95% CI 1.02-3.07）之间存在显著关联。相关分析还显示，男性白细胞计数与心脏代谢风险指标之间的关系比女性更为密切：这项研究提供了新的数据，表明中性粒细胞计数与 OSA 严重程度之间存在显著关联的仅是男性，而非女性。同样，男性白细胞参数与心脏代谢风险指标之间的关系也比女性更为明显。我们的研究结果表明，OSA 对白细胞参数及其与心脏代谢风险指标之间的关系具有性别特异性影响。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.