Challenges and strategies toward oncolytic virotherapy for leptomeningeal metastasis.

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-11-05 DOI:10.1186/s12967-024-05794-4

Jia-Li Zhao, Bi-Lin Lin, Chen Luo, Yan-Ling Yi, Peng Huang, Yu Chen, Sha Zhao, Zhen-Jie Huang, Xin-Yi Ma, Long Huang

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引用次数: 0

Abstract

Meningeal metastasis (LM) is commonly seen in the advanced stages of cancer patients, often leading to a rapid decline in survival time and quality of life. Currently, there is still a lack of standardized treatments. Oncolytic viruses (OVs) are a class of emerging cancer therapeutics with the advantages of selectively replicating in cancer cells, delivering various eukaryotic transgenes, inducing immunogenic cell death, and promoting anti-tumor immunity. Some studies applying OVs intrathoracically or intraperitoneally for the treatment of malignant pleural and peritoneal effusions have shown promising therapeutic effects. If OVs could be applied to treat LM, it would bring significant survival benefits to patients with LM. In this review, we analyzed past research on the use of viruses to treat meningeal metastasis, summarized the efficacy and safety demonstrated by the research results, and analyzed the feasibility of oncolytic virus therapy for meningeal metastasis. We also summarized the existing data to provide guidance for the development of OVs that can be injected into the cerebrospinal fluid (CSF).

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溶瘤病毒疗法治疗脑转移瘤的挑战和策略。

脑膜转移（LM）常见于晚期癌症患者，通常会导致生存时间和生活质量迅速下降。目前，仍缺乏标准化的治疗方法。肿瘤溶解病毒（OV）是一类新兴的癌症治疗药物，具有选择性复制癌细胞、传递各种真核转基因、诱导免疫性细胞死亡和促进抗肿瘤免疫等优势。一些应用 OVs 在胸腔内或腹腔内治疗恶性胸腔积液和腹腔积液的研究显示了良好的治疗效果。如果 OV 可用于治疗 LM，将为 LM 患者带来显著的生存益处。在这篇综述中，我们分析了过去利用病毒治疗脑膜转移瘤的研究，总结了研究成果所证明的有效性和安全性，并分析了溶瘤病毒治疗脑膜转移瘤的可行性。我们还总结了现有数据，为开发可注入脑脊液（CSF）的溶瘤病毒提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.