A U-shaped association between composite dietary antioxidant index and migraine in US adults: a nationwide cross-sectional study.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2024-11-05 DOI:10.1080/1028415X.2024.2423574

Tianqi Zuo, Jingya Yang, Yiyan Sun, Xiaotong Li, Hongyun Wu, Kunqi Han, Leiyong Zhao, Wei Peng

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引用次数: 0

Abstract

Background: The field of dietary therapies for migraine has grown in popularity. Less research has been conducted to establish the relationship between migraine and the composite dietary antioxidant index (CDAI), a crucial indicator for evaluating the overall combined effects of multiple dietary antioxidants. Therefore, this study addressed this gap based on the National Health and Nutrition Examination Survey (NHANES) database.

Methods: Multivariate logistic regression equations were used to investigate the relationship between CDAI and migraine, and smoothed-fitted curves were plotted. After a nonlinear relationship was discovered, the recursive algorithm and a two-stage linear regression model were employed to calculate the turning point. Additional stratified analyses were performed to explore differences between populations.

Results: This study included a total of 9,190 participants aged 20 years old or older. A U-shaped association was observed between the CDAI and migraine, with an inflection point of 0.2. They were negatively correlated before the inflection point with OR of 0.93 (95% CI = 0.88-0.97) and positively correlated after the inflection point with OR of 1.04 (95% CI = 1.01-1.07). This U-shaped relationship persisted among people aged <60 and ≥60 years, women, and people with BMI <30 and ≥30.

Conclusions: We identified a U-shaped association between CDAI and migraine in the U.S. adult population. Further case-control studies and experimental research are needed to explore the underlying mechanisms of action.

查看原文本刊更多论文

美国成年人综合膳食抗氧化指数与偏头痛之间的 U 型关系：一项全国性横断面研究。

背景：偏头痛的饮食疗法越来越受欢迎。偏头痛与膳食抗氧化剂综合指数（CDAI）之间的关系研究较少，而膳食抗氧化剂综合指数是评估多种膳食抗氧化剂综合效果的重要指标。因此，本研究以美国国家健康与营养调查（NHANES）数据库为基础，填补了这一空白：方法：采用多元逻辑回归方程研究 CDAI 与偏头痛之间的关系，并绘制平滑拟合曲线。发现非线性关系后，采用递归算法和两阶段线性回归模型计算转折点。另外还进行了分层分析，以探讨不同人群之间的差异：这项研究共纳入了 9 190 名 20 岁或 20 岁以上的参与者。CDAI与偏头痛之间呈U形关联，拐点为0.2。在拐点之前，两者呈负相关，OR值为0.93（95% CI = 0.88-0.97），而在拐点之后，两者呈正相关，OR值为1.04（95% CI = 1.01-1.07）。这种 U 型关系在老年人中持续存在：我们在美国成年人群中发现了 CDAI 与偏头痛之间的 U 型关系。需要进一步开展病例对照研究和实验研究，以探索其潜在的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.