Choroid plexus as a mediator of CNS inflammation in multiple sclerosis.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY
Alexandra Hochstetler, Maria K Lehtinen
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引用次数: 0

Abstract

The pathophysiology of multiple sclerosis (MS) remains poorly understood despite decades of tremendous research efforts. Advances in neuroradiography coupled with availability of unbiased approaches including spatial transcriptomics, proteomics, metabolomics, and lipidomics that are compatible with brain and fluid specimens from patients raise hope that discovery of novel disease drivers is on the horizon. Once thought to be little more than salty bathwater, our modern understanding of cerebrospinal fluid (CSF) suggests the CSF as a compelling, critical regulator of brain function in health and disease. Recent studies in the field have reinvigorated interest in CSF as a medium to better understand MS and to deliver disease-modifying therapies. In turn, the choroid plexus, an epithelial tissue located within each brain ventricle that regulates CSF and forms a key blood-CSF barrier, is uniquely positioned to orchestrate neuroinflammation associated with MS. In this perspective review, we will discuss what is known about the choroid plexus as a conductor of immune responses and how it may propagate neuroinflammation associated with MS via the CSF.

脉络丛是多发性硬化症中枢神经系统炎症的介质。
尽管经过几十年的艰苦研究,人们对多发性硬化症(MS)的病理生理学仍然知之甚少。神经放射成像技术的进步,以及与患者脑和脑脊液标本兼容的无偏见方法(包括空间转录组学、蛋白质组学、代谢组学和脂质组学)的出现,为发现新的疾病驱动因素带来了希望。我们对脑脊液(CSF)的现代认识表明,CSF 是健康和疾病状态下大脑功能的一个重要调节因子。该领域的最新研究重新激发了人们对脑脊液的兴趣,将其作为更好地了解多发性硬化症和提供疾病调节疗法的媒介。而脉络丛是位于每个脑室内的上皮组织,可调节 CSF 并形成关键的血液-CSF 屏障,在协调与多发性硬化症相关的神经炎症方面具有得天独厚的优势。在本视角综述中,我们将讨论脉络丛作为免疫反应导体的已知情况,以及脉络丛如何通过 CSF 传播与多发性硬化症相关的神经炎症。
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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
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