{"title":"Endodontic and periapical status of patients with osteoporosis: A cross-sectional study with age- and sex-matched controls.","authors":"Selin Goker Kamalı, Dilek Turkaydın","doi":"10.1016/j.adaj.2024.09.010","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The aim of the authors was to evaluate the periapical and endodontic conditions of patients with osteoporosis and compare them with those of age- and sex-matched controls. The association between bisphosphonate (BiP) use and periapical and endodontic status in patients with osteoporosis was also investigated.</p><p><strong>Methods: </strong>Panoramic radiographs of 711 patients with osteoporosis and 711 age- and sex-matched healthy patients were examined. The presence and number of root canal-filled teeth (RCFT), inadequate RCFT (iRCFT), and teeth with apical periodontitis (AP) were evaluated. BiP treatment history of patients with osteoporosis was also recorded.</p><p><strong>Results: </strong>No significant difference was observed between the osteoporosis group and control group in terms of endodontic and periapical conditions. Results of bivariate logistic regression analysis showed a positive association between the number of teeth with AP and the number of iRCFT with AP and osteoporosis, and a negative association between the number of RCFT with AP and osteoporosis. Among the patients with osteoporosis, 37.5% used BiPs, specifically alendronate, ibandronate, zoledronate, and risedronate (34.3%, 24.9%, 10.6%, 7.2%, respectively). In addition, the results showed a negative association between BiP use and RCFT.</p><p><strong>Conclusions: </strong>As the number of teeth with AP and number of iRCFT with AP increased, patients were more likely to be in the osteoporosis group. These findings imply that periapical lesions may enlarge and become more detectable in patients with osteoporosis with lower bone density, and enhanced inflammatory response.</p><p><strong>Practical implications: </strong>Dentists can collaborate with health care professionals to manage the overall health of patients with osteoporosis to reduce the impact of osteoporosis on oral health and effectively treat dental problems, such as AP.</p>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":"1022-1030"},"PeriodicalIF":3.1000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Dental Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.adaj.2024.09.010","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The aim of the authors was to evaluate the periapical and endodontic conditions of patients with osteoporosis and compare them with those of age- and sex-matched controls. The association between bisphosphonate (BiP) use and periapical and endodontic status in patients with osteoporosis was also investigated.
Methods: Panoramic radiographs of 711 patients with osteoporosis and 711 age- and sex-matched healthy patients were examined. The presence and number of root canal-filled teeth (RCFT), inadequate RCFT (iRCFT), and teeth with apical periodontitis (AP) were evaluated. BiP treatment history of patients with osteoporosis was also recorded.
Results: No significant difference was observed between the osteoporosis group and control group in terms of endodontic and periapical conditions. Results of bivariate logistic regression analysis showed a positive association between the number of teeth with AP and the number of iRCFT with AP and osteoporosis, and a negative association between the number of RCFT with AP and osteoporosis. Among the patients with osteoporosis, 37.5% used BiPs, specifically alendronate, ibandronate, zoledronate, and risedronate (34.3%, 24.9%, 10.6%, 7.2%, respectively). In addition, the results showed a negative association between BiP use and RCFT.
Conclusions: As the number of teeth with AP and number of iRCFT with AP increased, patients were more likely to be in the osteoporosis group. These findings imply that periapical lesions may enlarge and become more detectable in patients with osteoporosis with lower bone density, and enhanced inflammatory response.
Practical implications: Dentists can collaborate with health care professionals to manage the overall health of patients with osteoporosis to reduce the impact of osteoporosis on oral health and effectively treat dental problems, such as AP.
背景：作者的目的是评估骨质疏松症患者的根尖周和牙髓状况，并与年龄和性别匹配的对照组进行比较。同时还研究了骨质疏松症患者使用双磷酸盐（BiP）与根尖周和牙髓状况之间的关联：方法：研究人员检查了 711 名骨质疏松症患者和 711 名年龄与性别匹配的健康患者的全景 X 光片。评估了根管充填牙（RCFT）、根管充填不足牙（iRCFT）和根尖牙周炎牙（AP）的存在和数量。此外，还记录了骨质疏松症患者的 BiP 治疗史：结果：骨质疏松症组与对照组在牙髓病和根尖周炎方面无明显差异。双变量逻辑回归分析结果显示，有 AP 的牙齿数量、有 AP 的 iRCFT 数量与骨质疏松症呈正相关，而有 AP 的 RCFT 数量与骨质疏松症呈负相关。在骨质疏松症患者中，37.5% 的患者使用生物制剂，特别是阿仑膦酸钠、伊班膦酸钠、唑来膦酸钠和利塞膦酸钠（分别为 34.3%、24.9%、10.6% 和 7.2%）。此外，研究结果表明，BiP的使用与RCFT呈负相关：结论：随着有 AP 的牙齿数量和有 AP 的 iRCFT 数量的增加，患者更有可能属于骨质疏松症组。这些研究结果表明，骨质疏松症患者的骨密度较低，炎症反应增强，根尖周病变可能会扩大并更容易被发现：实际意义：牙科医生可与医护人员合作，对骨质疏松症患者的整体健康进行管理，以减少骨质疏松症对口腔健康的影响，并有效治疗根尖周炎等牙科问题。
期刊介绍：
There is not a single source or solution to help dentists in their quest for lifelong learning, improving dental practice, and dental well-being. JADA+, along with The Journal of the American Dental Association, is striving to do just that, bringing together practical content covering dentistry topics and procedures to help dentists—both general dentists and specialists—provide better patient care and improve oral health and well-being. This is a work in progress; as we add more content, covering more topics of interest, it will continue to expand, becoming an ever-more essential source of oral health knowledge.
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