Prevalence, Clinical Characteristics, and Relative Factors of Acquired Punctal Stenosis in Adult Allergic Conjunctivitis Patients.

IF 2.5 4区医学 Q3 ALLERGY

International Archives of Allergy and Immunology Pub Date : 2024-11-05 DOI:10.1159/000541369

Sihao Liu, Yubin Yu, Xiuping Liu, Ziyan Chen, Kaili Wu

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Abstract

Introduction: The objective of this study was to investigate the prevalence, characteristics, and risk factors of acquired punctal stenosis (APS) in adult patients with allergic conjunctivitis (AC).

Methods: This observational case series study included 210 adult AC patients at Zhongshan Ophthalmic Center. The demographic data were collected, and the ocular manifestations were assessed. Morphologies of AC patients' lacrimal puncta were evaluated and graded using the modified grading system by slit-lamp microscopy.

Results: There was 69.0% (145/210) of adult AC participants suffering from APS. Stenotic lacrimal puncta were present in 49.3% (414/840), with grade IIa being the most common (54.6%). Abnormal upper lacrimal puncta were more frequent than lower ones (89.0% vs. 73.1%, p = 0.001). AC patients with APS were significantly older than those without APS (p < 0.001). The percentage of patients with tear meniscus height (TMH) >0.3 mm was 40% in the APS group, compared to 12.5% in the non-APS group (p < 0.001). The age (OR = 1.589, 95% CI: 1.109-2.276, p = 0.012) and TMH (OR = 3.449, 95% CI: 1.224-9.719, p = 0.019) were positively associated with the occurrence of APS.

Conclusion: APS, especially the stenosis of upper lacrimal punctum, is frequently observed in the AC patients. Increased age and widened TMH are associated with the prevalence of APS in adult AC patients, suggesting a potential relationship between the long-term and recurrent course of AC and the development of APS.

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成人过敏性结膜炎患者获得性眼球结膜狭窄的患病率、临床特征和相关因素。

简介：本研究旨在调查过敏性结膜炎（AC）成人患者获得性穿刺狭窄（APS）的患病率、特征和风险因素：本研究旨在探讨过敏性结膜炎（AC）成人患者获得性穿刺口狭窄（APS）的患病率、特征和风险因素：这项观察性病例系列研究纳入了中山眼科中心的 210 名成人过敏性结膜炎患者。收集了人口统计学数据，并评估了眼部表现。通过裂隙灯显微镜，采用改良分级系统对AC患者泪小点的形态进行评估和分级：结果：69.0%（145/210）的AC成人患者患有APS。49.3%（414/840）的患者存在泪点狭窄，其中以 IIa 级最为常见（54.6%）。上泪点异常的比例高于下泪点（89.0% 对 73.1%，P = 0.001）。有 APS 的 AC 患者年龄明显大于无 APS 的患者（P < 0.001）。在APS组中，撕裂半月板高度（TMH）大于0.3毫米的患者比例为40%，而非APS组为12.5%（P < 0.001）。年龄（OR = 1.589，95% CI：1.109-2.276，p = 0.012）和 TMH（OR = 3.449，95% CI：1.224-9.719，p = 0.019）与 APS 的发生呈正相关：结论：APS，尤其是上泪道穿刺孔狭窄，经常出现在鼻咽癌患者中。年龄的增加和 TMH 的增宽与 AC 成人患者 APS 的发生率有关，这表明 AC 的长期和反复病程与 APS 的发生之间存在潜在的关系。

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来源期刊

International Archives of Allergy and Immunology 医学-过敏

CiteScore

5.60

自引率

3.60%

发文量

105

审稿时长

2 months

期刊介绍： ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.