A comparative analysis of PLA and PCL microparticles for hydrophilic and hydrophobic drugs.

IF 3 4区 医学 Q2 CHEMISTRY, APPLIED
Subrat Kumar Panigrahi, Sougat Das, Saptarshi Majumdar
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引用次数: 0

Abstract

This study aims to investigate Polylactic Acid (PLA) and Polycaprolactone (PCL) polymers for microencapsulation of hydrophilic and hydrophobic anti-glaucoma drugs using an emulsion-based solvent evaporation technique. Microparticle size was analysed using optical microscopy, while drug-polymer interactions through Dynamic-Light-Scattering (DLS) and Fourier-Transform-Infra-red/Attenuated-Total-Reflection spectroscopy (FTIR/ATR). In vitro, drug release studies were performed to investigate drug encapsulation and release profiles. Spherical microparticles, with particle size 94 ± 6.9 μm for PCL-based and 100 ± 3.74 μm for PLA-based formulation, were obtained. Drug release studies showed 100% release over about 32 days, with encapsulation efficiency (%EE) and drug loading (%w/w) reaching up to 95 and 2.84% for PLA-based and 97 and 2.91% for PCL-based microparticles, respectively. DLS studies reveal an increase in hydrodynamic radius (RH), which correlates to enhanced drug encapsulation. So, the nature of the drug and polymer significantly impacts drug encapsulation and release, with drug-polymer interactions playing a crucial role alongside experimental parameters.

聚乳酸(PLA)和聚苯乙烯(PCL)微颗粒用于亲水性和疏水性药物的比较分析。
本研究旨在利用基于乳液的溶剂蒸发技术,研究聚乳酸(PLA)和聚己内酯(PCL)聚合物用于亲水性和疏水性抗青光眼药物的微囊化。使用光学显微镜分析了微粒的大小,并通过动态光散射(DLS)和傅立叶变换红外/衰减全反射光谱(FTIR/ATR)分析了药物与聚合物之间的相互作用。体外进行了药物释放研究,以调查药物的封装和释放情况。获得的球形微粒粒径为:基于 PCL 的配方为 94 ± 6.9 μm,基于 PLA 的配方为 100 ± 3.74 μm。药物释放研究表明,在大约 32 天的时间里,药物释放率达到 100%,聚乳酸基微粒的封装效率(%EE)和载药量(%w/w)分别达到 95%和 2.84%,聚CL 基微粒的封装效率和载药量分别达到 97%和 2.91%。DLS 研究显示,流体力学半径(RH)增加,这与药物包囊能力增强有关。因此,药物和聚合物的性质对药物的封装和释放有重大影响,药物与聚合物之间的相互作用与实验参数一起发挥着至关重要的作用。
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来源期刊
Journal of microencapsulation
Journal of microencapsulation 工程技术-工程:化工
CiteScore
6.30
自引率
2.60%
发文量
39
审稿时长
3 months
期刊介绍: The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.
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