Spatiotemporal Dynamics of Periodic and Aperiodic Brain Activity Under Peripheral Nerve Stimulation With Acupuncture

Abstract

Brain activities are a mixture of periodic and aperiodic components, manifesting in the power spectral density (PSD) as rhythmic oscillations with spectral peaks and broadband fluctuations. Periodic oscillatory properties of brain response to external stimulation are widely studied, while aperiodic component responses remain unclear. Here, we investigate spatiotemporal dynamics of periodic and aperiodic brain activity under peripheral nerve stimulation with acupuncture by parameterization of power spectra of EEG signals. Regarding periodic brain activity, spectral peak in delta band emerges in frontal and central brain regions indicates a typical phenomenon of neural entrainment, which is formed by coupling periodic brain activity to external rhythmic acupuncture stimulation. In addition, the statistical results show that alpha periodic power is an important indicator for characterizing the modulatory effects of acupuncture on periodic brain activity. As for aperiodic brain activity, broadband EEG spectral trend analysis demonstrates a steeper aperiodic slope in left parietal lobe and a stronger negative correlation with the aperiodic offset under acupuncture compared with resting state, with the absolute value of correlation coefficient increasing from 0.27 to 0.50. Based on the two parameters that can best characterize the acupuncture effect, alpha periodic power and aperiodic slope, the accurate decoding of acupuncture manipulation is realized with AUC = 0.87. This work shows the modulatory effect of peripheral nerve stimulation with acupuncture on the brain activity by characterizing the periodic and aperiodic spectrum features of EEG, providing new insights into the comprehensive understanding of the response processes of human brain to acupuncture stimulation.