Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities.

IF 7.8 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Cold Spring Harbor perspectives in medicine Pub Date : 2024-11-05 DOI:10.1101/cshperspect.a041814

Navdeep S Chandel, Karen H Vousden, Ralph J DeBerardinis

引用次数: 0

Abstract

Cancer cells undergo changes in metabolism that distinguish them from non-malignant tissue. These may provide a growth advantage by promoting oncogenic signaling and redirecting intermediates to anabolic pathways that provide building blocks for new cellular components. Cancer metabolism is far from uniform, however, and recent work has shed light on its heterogenity within and between tumors. This work is also revealing how cancer metabolism adapts to the tumor microenvironment, as well as ways in which we may capitalize on metabolic changes in cancer cells to create new therapies.

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癌症代谢：历史里程碑、新概念和新机遇》（Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities）。

癌细胞的新陈代谢发生变化，使其有别于非恶性组织。这些变化可能会促进致癌信号的传递，并将中间产物重新导向合成代谢途径，从而为新的细胞成分提供构建基块，从而提供生长优势。然而，癌症代谢远非千篇一律，最近的研究揭示了肿瘤内部和肿瘤之间的异质性。这项工作还揭示了癌症代谢如何适应肿瘤微环境，以及我们如何利用癌细胞的代谢变化创造新疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

14.30

自引率

1.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.