Skin Barrier Parameters in Acne Vulgaris versus Normal Controls: A Cross-Sectional Analytic Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S476004

Siriorn Sukanjanapong, Monthanat Ploydaeng, Penpun Wattanakrai

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Abstract

Aim: Data of objective skin barrier parameters in acne patients with and without therapy compared with normal controls are limited. This information could provide more insight into the pathogenesis of acne vulgaris and optimal acne treatment.

Purpose: To measure and compare skin barrier parameters in a large cohort of acne patients with and without therapy compared with normal controls.

Methods: This cross-sectional analytic study was conducted on healthy Thai volunteers. After completing a questionnaire on their general information and skincare routine, volunteers received a full skin examination and were divided into subjects with and without acne. Skin barrier parameters, including the transepidermal water loss (TEWL), skin hydration and sebum production were measured and compared between the two groups. Factors that may affect each parameter were analysed and adjusted for in a multivariate regression analysis. In addition, data from acne patients with and without treatment were evaluated.

Results: The study included 316 volunteers (164 acne patients, 152 controls), mostly female (79% acne, 78% controls). The mean age of the acne group was considerably lower than that of the control group (34 vs 48.6 years (p < 0.001)). Acne patients showed significantly higher TEWL (13.16 vs 10.63 g/m²/day, p < 0.001), sebum production (median 3 vs 0 A.U, p = 0.002), and skin hydration (244.60 vs 222.60 uS, p = 0.001). These differences remained significant after adjusting for confounding factors. Additionally, significant differences were observed between controls, acne. Patients receiving and not receiving acne medications. The highest TEWL was observed in acne patients receiving treatment, followed by untreated acne patients and normal controls (p = 0.0003). Skin hydration exhibited a comparable pattern (p = 0.03).

Conclusion: There were significantly higher TEWL, sebum production and hydration in acne patients. Acne treatment further impaired the skin barrier. These findings support the possible benefits of moisturisers with barrier-enhancing properties in patients receiving acne medications.

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大疱性痤疮与正常对照组的皮肤屏障参数：横断面分析研究

目的：与正常对照组相比，痤疮患者接受治疗和未接受治疗时的客观皮肤屏障参数数据有限。目的：测量并比较大量接受和未接受治疗的痤疮患者与正常对照组的皮肤屏障参数：这项横断面分析研究以健康的泰国志愿者为对象。志愿者在填写了有关其一般信息和护肤程序的问卷后，接受了全面的皮肤检查，并被分为有痤疮和无痤疮的受试者。测量并比较了两组受试者的皮肤屏障参数，包括经表皮失水（TEWL）、皮肤水合作用和皮脂分泌。在多变量回归分析中，对可能影响各参数的因素进行了分析和调整。此外，还评估了接受和未接受治疗的痤疮患者的数据：研究包括 316 名志愿者（164 名痤疮患者，152 名对照组），大部分为女性（痤疮患者占 79%，对照组占 78%）。痤疮组的平均年龄大大低于对照组（34 岁对 48.6 岁（P < 0.001））。痤疮患者的 TEWL（13.16 vs 10.63 g/m²/天，p < 0.001）、皮脂分泌（中位数 3 vs 0 A.U，p = 0.002）和皮肤水合度（244.60 vs 222.60 uS，p = 0.001）均明显高于对照组。在对混杂因素进行调整后，这些差异仍然显著。此外，对照组和痤疮患者之间也存在明显差异。接受和未接受痤疮药物治疗的患者。接受治疗的痤疮患者的 TEWL 最高，其次是未接受治疗的痤疮患者和正常对照组（p = 0.0003）。皮肤水合度显示出相似的模式（p = 0.03）：结论：痤疮患者的 TEWL、皮脂分泌和水合作用均明显高于正常人。痤疮治疗进一步损害了皮肤屏障。这些研究结果表明，具有增强皮肤屏障功能的润肤霜可能对接受痤疮治疗的患者有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.