Multicomorbidity in Psoriasis Vulgaris: A Retrospective Analysis.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S485453

Bilge Fettahlioglu Karaman, Irem Ayse Salkin Cinki, Varol Lutfu Aksungur

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Abstract

Background: The frequencies of comorbidities in patients with psoriasis have been compared to that in the general population in many studies. Moreover, several studies have investigated the risk factors influencing the number of comorbidities in patients with psoriasis. However, a few studies have examined clusters of patients with psoriasis according to their comorbidities. In this study, we aimed to explore the multicomorbidities of psoriasis vulgaris in terms of risk factors and clusters.

Methods: All diagnoses of 452 patients with psoriasis vulgaris were extracted from electronic medical records of a tertiary hospital. Binary association coefficients were calculated for all pairs of comorbidities. Subsequently, a hierarchical cluster analysis was performed.

Results: Among the patients, 30.5% had no comorbidities, 28.8% had a single comorbidity, and 40.7% had multiple comorbidities. The number of comorbidities was positively associated with age and follow-up duration but not with sex. The most striking cluster of comorbidities was composed of diabetes, hepatosteatosis, hyperlipidemia, hypertension, cancer, and cardiovascular disease.

Conclusion: This cluster could be explained by cardiometabolic multimorbidity. Exploring such clusters may provide a more forward-looking perspective for the management of psoriasis patients.

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寻常型银屑病的多重并发症：回顾性分析

背景：许多研究将银屑病患者的合并症发生率与普通人群进行了比较。此外，一些研究还调查了影响银屑病患者合并症数量的风险因素。然而，很少有研究根据银屑病患者的合并症对其进行分组。在本研究中，我们旨在从风险因素和群集方面探讨寻常型银屑病的多重合并症：方法：从一家三级医院的电子病历中提取了 452 名寻常型银屑病患者的所有诊断结果。计算了所有合并症的二元关联系数。随后进行了分层聚类分析：结果：患者中30.5%无合并症，28.8%有单一合并症，40.7%有多种合并症。合并症的数量与年龄和随访时间呈正相关，但与性别无关。糖尿病、肝硬化、高脂血症、高血压、癌症和心血管疾病是最显著的一组合并症：结论：这一疾病群可以用心脏代谢性多病来解释。对此类疾病群的探索可为银屑病患者的管理提供更具前瞻性的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.