Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases.

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Tong Nie, Li You, Fang Tang, Yanhui Duan, Eugenie Nepovimova, Kamil Kuca, Qinghua Wu, Wei Wei
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Abstract

Background: Age-related neurodegenerative diseases (NDs) pose a formidable challenge to healthcare systems worldwide due to their complex pathogenesis, significant morbidity, and mortality. Scope and Approach: This comprehensive review aims to elucidate the central role of the microbiotagut- brain axis (MGBA) in ND pathogenesis. Specifically, it delves into the perturbations within the gut microbiota and its metabolomic landscape, as well as the structural and functional transformations of the gastrointestinal and blood-brain barrier interfaces in ND patients. Additionally, it provides a comprehensive overview of the recent advancements in medicinal and dietary interventions tailored to modulate the MGBA for ND therapy.

Conclusion: Accumulating evidence underscores the pivotal role of the gut microbiota in ND pathogenesis through the MGBA. Dysbiosis of the gut microbiota and associated metabolites instigate structural modifications and augmented permeability of both the gastrointestinal barrier and the blood-brain barrier (BBB). These alterations facilitate the transit of microbial molecules from the gut to the brain via neural, endocrine, and immune pathways, potentially contributing to the etiology of NDs. Numerous investigational strategies, encompassing prebiotic and probiotic interventions, pharmaceutical trials, and dietary adaptations, are actively explored to harness the microbiota for ND treatment. This work endeavors to enhance our comprehension of the intricate mechanisms underpinning ND pathogenesis, offering valuable insights for the development of innovative therapeutic modalities targeting these debilitating disorders.

老年性神经退行性疾病中的微生物群-肠-脑轴
背景:与年龄相关的神经退行性疾病(NDs)发病机制复杂、发病率和死亡率高,给全球医疗保健系统带来了巨大挑战。范围和方法:本综述旨在阐明微生物-肠-脑轴(MGBA)在 ND 发病机制中的核心作用。具体而言,它深入研究了 ND 患者肠道微生物群及其代谢组的扰动,以及胃肠道和血脑屏障界面的结构和功能变化。此外,该报告还全面概述了为治疗 ND 而调整 MGBA 的药物和饮食干预措施的最新进展:不断积累的证据强调了肠道微生物群通过 MGBA 在 ND 发病机制中的关键作用。肠道微生物群和相关代谢产物的菌群失调会导致胃肠道屏障和血脑屏障(BBB)的结构改变和通透性增加。这些改变有助于微生物分子通过神经、内分泌和免疫途径从肠道进入大脑,从而可能导致 NDs 的病因。目前正在积极探索多种研究策略,包括益生菌和益生菌干预、药物试验和饮食调整,以利用微生物群治疗 ND。这项工作致力于提高我们对 ND 发病机制的复杂机制的理解,为开发针对这些衰弱性疾病的创新治疗模式提供宝贵的见解。
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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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