Tactile mechanisms and afferents underlying the rat pup transport response.

IF 8.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Current Biology Pub Date : 2024-12-02 Epub Date: 2024-11-04 DOI:10.1016/j.cub.2024.10.016
Zheyi Ni, Connor Neifert, Arturo Rosete, Abdalla M Albeely, Yu Yang, Marta Pratelli, Michael Brecht, Ann M Clemens
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引用次数: 0

Abstract

Juvenile rodents and other altricial mammals react with calming, immobility, and postural modifications to parental pickup, a set of behaviors referred to as the transport response.1,2,3,4,5 Here, we investigate sensory mechanisms underlying the rat transport response. Grasping rat pups in anterior neck positions evokes strong immobility and folding up of feet, whereas more posterior grasping has lesser effects on immobility and foot position. Transport responses are enhanced by slow (1 Hz), and even more so by fast (4 Hz), gentle shaking and translation, features consistent with parental transport. With lateral grasping, the forepaw below the grasping position points downward and the forepaw lateral to the grasping position points upward and medially. Such forepaw adjustments put the pup's center of gravity below the grasping point, optimizing pup transportability. Tactile stimuli on the back, belly, tail, whisker, dorsal forepaws, and dorsal hind-paws do not significantly affect behavior of anterior-neck-held pups. Instead, ground contact, or paw stimulation consistent with ground contact, disrupts transport responses. We identify afferents mediating transport response by examining membrane labeling with FM 1-436 following anterior neck grasping. We observe a dense innervation of the anterior-neck-skin region (∼30 terminals/mm2). We find an age-related decrease of cytochrome oxidase reactivity in the rat somatosensory cortical neck representation, a possible correlate to developmental decrease in pup transport response. We conclude that anterior neck grasping and loss of ground contact trigger calming and postural adjustments for parental transport in rat pups, responses putatively driven from the densely innervated anterior neck skin.

大鼠幼崽运输反应的触觉机制和传入神经
幼年啮齿类动物和其他初生哺乳动物对父母抱起幼鼠时会做出镇静、不动和姿势改变等反应,这些行为被称为迁移反应1,2,3,4,5。在前颈部位抓住幼鼠会引起幼鼠强烈的不动和脚部折叠,而在后颈部位抓住幼鼠则对幼鼠的不动和脚部位置影响较小。缓慢(1赫兹)、甚至快速(4赫兹)的轻微摇晃和平移都会增强迁移反应,这些特征与亲代迁移一致。侧向抓握时,抓握位置下方的前爪指向下方,抓握位置外侧的前爪指向上方和内侧。这样的前爪调整使幼犬的重心低于抓握点,从而优化了幼犬的运输能力。背部、腹部、尾巴、胡须、前爪背侧和后爪背侧的触觉刺激对颈前抓握幼鼠的行为没有显著影响。相反,地面接触或与地面接触一致的爪刺激会扰乱运输反应。我们通过检查前颈抓握后的 FM 1-436 膜标记,确定了介导运输反应的传入神经。我们观察到颈前皮肤区域有密集的神经支配(每平方毫米有 30 个终端)。我们发现大鼠躯体感觉皮层颈部表征中细胞色素氧化酶反应性的下降与年龄有关,这可能与幼鼠运输反应的发育下降有关。我们的结论是,前颈抓握和失去地面接触会触发大鼠幼崽的平静和姿势调整,以适应父母的运输,这些反应可能是由前颈皮肤的密集神经支配引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Biology
Current Biology 生物-生化与分子生物学
CiteScore
11.80
自引率
2.20%
发文量
869
审稿时长
46 days
期刊介绍: Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.
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