Developmental encoding of natural sounds in the mouse auditory cortex.

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Stefano Zucca, Chiara La Rosa, Tommaso Fellin, Paolo Peretto, Serena Bovetti
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Abstract

Mice communicate through high-frequency ultrasonic vocalizations, which are crucial for social interactions such as courtship and aggression. Although ultrasonic vocalization representation has been found in adult brain areas along the auditory pathway, including the auditory cortex, no evidence is available on the neuronal representation of ultrasonic vocalizations early in life. Using in vivo two-photon calcium imaging, we analyzed auditory cortex layer 2/3 neuronal responses to USVs, pure tones (4 to 90 kHz), and high-frequency modulated sweeps from postnatal day 12 (P12) to P21. We found that ACx neurons are tuned to respond to ultrasonic vocalization syllables as early as P12 to P13, with an increasing number of responsive cells as the mouse age. By P14, while pure tone responses showed a frequency preference, no syllable preference was observed. Additionally, at P14, USVs, pure tones, and modulated sweeps activate clusters of largely nonoverlapping responsive neurons. Finally, we show that while cell correlation decreases with increasing processing of peripheral auditory stimuli, neurons responding to the same stimulus maintain highly correlated spontaneous activity after circuits have attained mature organization, forming neuronal subnetworks sharing similar functional properties.

小鼠听觉皮层对自然声音的发育编码
小鼠通过高频超声波发声进行交流,这对求偶和攻击等社会互动至关重要。虽然在听觉通路的成年脑区(包括听觉皮层)发现了超声波发声表征,但没有证据表明超声波发声在生命早期的神经元表征。利用体内双光子钙成像技术,我们分析了听觉皮层第 2/3 层神经元对 USV、纯音(4 至 90 kHz)和高频调制扫频的反应。我们发现,ACx神经元早在出生后第12天至第13天就能对超声发声音节做出反应,随着小鼠年龄的增长,反应细胞的数量也在增加。到 P14 时,虽然纯音反应显示出频率偏好,但没有观察到音节偏好。此外,在 P14 时,USV、纯音和调制扫频激活的反应神经元群基本不重叠。最后,我们发现,虽然细胞相关性会随着外周听觉刺激处理的增加而降低,但对相同刺激做出反应的神经元在电路组织成熟后仍会保持高度相关的自发活动,形成具有相似功能特性的神经元子网络。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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