Prevalence of frailty in the TIA clinic and its associations with mortality.

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Amy R Elliott, Amit K Mistri, David Eveson, Jatinder S Minhas, Terence J Quinn, Thompson G Robinson, Lucy C Beishon
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引用次数: 0

Abstract

Introduction Frailty is a clinical syndrome of increased vulnerability to stressors. Frailty is associated with adverse outcomes after stroke, but frailty and transient ischaemic attack (TIA) are less well described. Methods Retrospective analysis of patients referred by the emergency department (ED) to TIA clinic (01/01/2016-12/03/2022), linked to hospital records for electronic follow-up. Only those with Clinical Frailty Scale (CFS) recorded within two weeks of clinic were included. Prevalence of frailty was determined based on CFS score >4. Hazard ratios (HR) for mortality were determined through Cox proportional hazard regression, adjusted for prognostic factors. Where repeat CFS data were available, temporal change in frailty was recorded (~15 months). Results Of 1185 patients included, 53.5% (n=634) had frailty. Patients with frailty tended to be older (median age 81 vs 74 years, p<0.001) and female (53.9% vs 39.9% p<0.001). Of 335 diagnosed with TIA following review, 61.2% (n=205) were frail. Prevalence of frailty by clinic diagnosis was: TIA 61.2% (205/335); stroke 46.7% (128/274); other diagnoses 52.3% (301/575). In TIA patients and the whole cohort (WC), frailty (TIA:HR:2.69 [95%CI:1.23-5.87, p=0.013], WC:2.58 [95%CI:1.64-4.08, p<0.001]) and increasing age [HR:1.07 95%CI:1.04-1.12], were predictive of mortality. In stroke patients, only increasing age was predictive of death (HR:1.11 [95%CI:1.04-1.19, p=0.003]). Of 414 patients with repeat CFS, median interval 15 months, median change was +1 point (IQR:0-2). Conclusion Frailty is common in TIA and becomes more common following TIA. Strength of association of frailty with poor outcome was greater for TIA patients than for those with stroke. Routine assessment of frailty may be a useful addition to TIA services.

TIA 诊所中体弱的普遍性及其与死亡率的关系。
导言:虚弱是一种更容易受到压力影响的临床综合征。虚弱与中风后的不良预后有关,但虚弱与短暂性脑缺血发作(TIA)的关系却鲜为人知。方法 对急诊科(ED)转诊至 TIA 诊所的患者进行回顾性分析(01/01/2016-12/03/2022),并与医院记录相连进行电子随访。仅纳入在门诊两周内有临床虚弱量表(CFS)记录的患者。死亡率的危险比(HR)通过考克斯比例危险回归确定,并对预后因素进行调整。如果有重复的 CFS 数据,则记录虚弱程度的时间变化(约 15 个月)。结果 在纳入的 1185 名患者中,53.5%(n=634)患有虚弱症。体弱患者往往年龄较大(中位年龄为 81 岁对 74 岁,p
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来源期刊
Cerebrovascular Diseases
Cerebrovascular Diseases 医学-临床神经学
CiteScore
4.50
自引率
0.00%
发文量
90
审稿时长
1 months
期刊介绍: A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.
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