Nanoparticles for Delivering Micro and Macromolecules for the Management of Diabetic Wounds

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2024-11-05 DOI:10.1002/cbf.70006

Vidyasrilekha Sanapalli, Md Azizul Haque, Bharat Kumar Reddy Sanapalli, Veera Venkata Satyanarayana Reddy Karri, Tonmoy Kumar Mondal, Paritosh Barai, Md. Rabiul Islam, Farha Farahim, Talat Ali, Hasi Rani Barai, Madhusudan Roy

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引用次数: 0

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that affects most vital organs in the body. Approximately 463 million people were diagnosed with DM worldwide in 2019. The incidence of DM is estimated to increase by 700 million by 2045. Diabetic wounds (DWs) are among the most severe complications in people suffering from DM. Although diverse standard care treatment strategies are available for DWs, they are unsatisfactory because of the multifactorial pathophysiology of DWs. Cutting-edge nanoparticles are increasingly being used in treating DWs. In particular, few nanoparticles naturally act as ROS scavengers, promote angiogenesis, exhibit antimicrobial activity, and form the extracellular matrix, which is considered beneficial for DW healing. The current review focused on the pivotal potential of the present nanoparticles for DW healing, emphasizing and highlighting the use of the nanoparticles in delivering micro and macromolecules in tissue regeneration for DW healing and future perspectives.

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用于治疗糖尿病伤口的微分子和大分子纳米颗粒。

糖尿病（DM）是一种慢性代谢性疾病，会影响人体大部分重要器官。2019 年，全球约有 4.63 亿人被诊断患有糖尿病。预计到 2045 年，糖尿病发病率将增加 7 亿。糖尿病伤口（DW）是糖尿病患者最严重的并发症之一。虽然针对糖尿病伤口有多种标准护理治疗策略，但由于糖尿病伤口的病理生理学是多因素的，因此这些策略并不令人满意。前沿的纳米粒子正越来越多地被用于治疗 DWs。特别是，少数纳米颗粒天然具有清除 ROS、促进血管生成、抗菌和形成细胞外基质的作用，这些作用被认为有利于 DW 的愈合。目前的综述侧重于目前纳米粒子在 DW 愈合方面的关键潜力，强调和突出了纳米粒子在组织再生中输送微分子和大分子以促进 DW 愈合的用途和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.