Anticholinergic Burden and Dry Mouth Problems Among Older Adults (≥ 50 Years) Receiving Dental Care—A Retrospective, Cross-Sectional Analysis

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2024-11-05 DOI:10.1002/cre2.70009

Christoph Matthias Schoppmeier, Isabel Deeg, Michael Jochen Wicht, Anna Greta Barbe

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引用次数: 0

Abstract

Objectives

Anticholinergics cause dry mouth and are highly relevant for dentists, but little is known about the relationships between intake and the occurrence of subjective and objective dry mouth with age. The German anticholinergic burden score (GACB) is a novel anticholinergic score that re-evaluates medications, particularly, those with classification discrepancies.

Material and Methods

We retrospectively investigated the GACB in older patients receiving dental care, evaluated whether GACB is related to xerostomia and unstimulated salivary secretion, and determined the influence of increasing age (beginning at 50 years of age). The GACB score quantified cumulative anticholinergic effects: 0 for no effect, 1 for possible, 2 for moderate, and 3 for strong. Cross-sectional data in patients ≥ 50 years were collected, including xerostomia with the visual analog scale, unstimulated salivary flow rates, and the GACB scores.

Results

Among 172 patients (mean age 65.67 ± 9.51 years), 23.8% had a GACB score ≥ 1. A moderate negative correlation was observed between GACB and unstimulated salivary flow rates ( $\overset{̅}{r}$ = −0.51). Patients with GACB ≥ 1 had fewer teeth (mean 21.76 ± 5.41) than those with GACB = 0 (24.07 ± 5.57). Moreover, unstimulated hyposalivation was observed in 61.0% with GACB ≥ 1 versus 6.8% with GACB = 0 (p < 0.001). Escalating chronic systemic conditions and prescribed medications were recorded with increasing age; those aged 76–80 years had the highest burden.

Conclusions

The GACB quickly and reliably assesses anticholinergic exposure and risks for oral health in older patients. Routine use in those aged ≥ 50 years could enable early identification of risks and initiation of preventive dental measures.

Trial Registration

German Registry for Clinical Trials: DRKS00032877 (https://www.germanctr.de; date of registration: 17.10.2023).

查看原文本刊更多论文

接受牙科治疗的老年人（≥ 50 岁）的抗胆碱能负担和口干问题--一项回顾性横断面分析。

目的：抗胆碱能药物会导致口干，与牙科医生密切相关，但人们对其摄入量与随着年龄增长而出现的主观和客观口干之间的关系知之甚少。德国抗胆碱能药物负担评分（GACB）是一种新型抗胆碱能药物评分方法，可重新评估药物，尤其是那些分类不一致的药物：我们对接受牙科治疗的老年患者的 GACB 进行了回顾性调查，评估了 GACB 是否与口腔干燥症和非刺激性唾液分泌有关，并确定了年龄增长（从 50 岁开始）的影响。GACB 评分量化了累积的抗胆碱能效应：0 表示无影响，1 表示可能有影响，2 表示中度影响，3 表示强烈影响。收集了年龄≥50 岁患者的横断面数据，包括口干症视觉模拟量表、非刺激性唾液流量和 GACB 评分：在 172 名患者（平均年龄为 65.67 ± 9.51 岁）中，23.8% 的患者 GACB 评分≥1。GACB 与非刺激唾液流速之间呈中度负相关（r ̅ $\mathop{r}\limits^{̅}$ =-0.51）。与 GACB = 0（24.07 ± 5.57）的患者相比，GACB ≥ 1 的患者的牙齿数量较少（平均 21.76 ± 5.41）。此外，61.0% 的 GACB ≥ 1 患者与 6.8% 的 GACB = 0 患者相比，出现了非刺激性唾液分泌过少（p 结论：GACB ≥ 1 患者的唾液分泌过少率低于 GACB = 0 患者：GACB 可以快速、可靠地评估老年患者的抗胆碱能暴露和口腔健康风险。在年龄≥50 岁的人群中常规使用该方法，可及早识别风险并启动牙科预防措施：试验注册：德国临床试验注册中心：DRKS00032877 (https://www.germanctr.de; 注册日期：17.10.2023)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.