Impact of intravenous infusion of lidocaine on intrapulmonary shunt and postoperative cognitive function in patients undergoing one-lung ventilation.

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Clinical and Experimental Medicine Pub Date : 2024-11-06 DOI:10.17219/acem/192879

Dawei Yang, Qian Yang, Yixing Wang, Fengxia Liu, Zhi Xing, Shitong Li, Jianyou Zhang

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引用次数: 0

Abstract

Background: Intravenous infusion of lidocaine as an anesthesia adjuvant can improve patient outcomes, but its impact on intrapulmonary shunt during one-lung ventilation (OLV) has not been clarified.

Objectives: To determine the effect of intravenous lidocaine infusion on intrapulmonary shunt during OLV and postoperative cognitive function in video-assisted thoracoscopic surgery (VATS).

Material and methods: Sixty patients who underwent OLV for thoracic surgery were randomized to receive intravenous infusion of lidocaine (lidocaine group, n = 30) or normal saline (control group, n = 30) for anesthesia induction. Arterial and venous blood gases were measured during two-lung ventilation and at 15 and 30 min after OLV (OLV + 15 and OLV + 30). The Mini-Mental State Examination was administered before the surgery and at postoperative 12 months to assess patient cognitive function.

Results: No significant difference was found in intrapulmonary shunt fraction (Qs/Qt) between the lidocaine group and the control group at OLV + 15 (p = 0.493) and OLV + 30 (p = 0.754). The lidocaine group used significantly lower doses of propofol and remifentanil compared to the control group (both p < 0.001). Furthermore, no significant difference was observed in the incidence of postoperative cognitive dysfunction between the lidocaine group and the control group at 1 year post-operation (3.3% vs 6.7%, p = 0.554).

Conclusions: Intravenous lidocaine administered in VATS had no significant impact on intrapulmonary shunt during OLV or postoperative cognitive function. However, it significantly reduced the doses of anesthetics used during the surgery.

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静脉注射利多卡因对单肺通气患者肺内分流和术后认知功能的影响。

背景：静脉输注利多卡因作为麻醉辅助剂可改善患者预后，但其对单肺通气（OLV）期间肺内分流的影响尚未明确：目的：确定静脉注射利多卡因对视频辅助胸腔镜手术（VATS）单肺通气期间肺内分流和术后认知功能的影响：60名接受胸腔镜手术OLV的患者被随机分为利多卡因组（利多卡因组，n = 30）和生理盐水组（对照组，n = 30）。在双肺通气期间、OLV 后 15 分钟和 30 分钟（OLV + 15 和 OLV + 30）测量动脉和静脉血气。术前和术后 12 个月进行了迷你精神状态检查，以评估患者的认知功能：结果：利多卡因组和对照组在 OLV + 15（p = 0.493）和 OLV + 30（p = 0.754）时的肺内分流分数（Qs/Qt）无明显差异。与对照组相比，利多卡因组使用的异丙酚和瑞芬太尼剂量明显较低（均 p < 0.001）。此外，在术后一年，利多卡因组与对照组的术后认知功能障碍发生率无明显差异（3.3% vs 6.7%，p = 0.554）：结论：在 VATS 中静脉注射利多卡因对 OLV 期间的肺内分流或术后认知功能没有显著影响。结论：在 VATS 手术中静脉注射利多卡因对 OLV 术中的肺内分流和术后认知功能没有明显影响，但却大大减少了手术中使用的麻醉剂剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

3.70

自引率

4.80%

发文量

153

审稿时长

6-12 weeks

期刊介绍： Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.