The Neoteric Paradigm of Biomolecule-Functionalized Albumin-Based Targeted Cancer Therapeutics

IF 3.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

AAPS PharmSciTech Pub Date : 2024-11-05 DOI:10.1208/s12249-024-02977-6

Swati Gunjkar, Ujala Gupta, Rahul Nair, Priti Paul, Mayur Aalhate, Srushti Mahajan, Indrani Maji, Manish K. Chourasia, Santosh Kumar Guru, Pankaj Kumar Singh

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Abstract

Albumin is a nature-derived, versatile protein carrier, that has been explored extensively by researchers for anticancer drug delivery due to its role in enhancing drug stability, solubility, circulation time, targeting capabilities, and overall therapeutic efficacy. Albumin nanoparticles possess inherent biocompatibility, biodegradability, and passive tumor-targeting ability due to the enhanced permeability and retention effect. However, non-specific accumulation of cytotoxic agents in healthy tissues remains a challenge. In this paper, the functionalization of albumin nanoparticles using various biomolecules including antibodies, nucleic acids, proteins and peptides, vitamins, chondroitin sulfate, hyaluronic acid, and lactobionic acid have been discussed which enables specific recognition and binding to cancer cells. Furthermore, we highlight the supremacy of such a targeted approach in tumor-specific drug delivery, minimization of off-target effects, potential improvement in therapeutic efficacy, cellular internalization, reduced side effects, and better clinical outcomes. This review centers on how they have revolutionized the field of biomedical research and tuned into an excellent targeted approach. In conclusion, this review highlights in detail the role of albumin as a nanocarrier for tumor-targeted delivery using biomolecules as ligands.

Graphical Abstract

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基于生物分子功能化白蛋白的癌症靶向治疗新范例。

白蛋白是一种来源于自然界的多功能蛋白质载体，由于其在增强药物稳定性、溶解性、循环时间、靶向能力和整体疗效方面的作用，研究人员在抗癌药物递送方面进行了广泛的探索。白蛋白纳米粒子具有固有的生物相容性、生物可降解性以及因渗透性和滞留效应增强而产生的被动肿瘤靶向能力。然而，细胞毒剂在健康组织中的非特异性蓄积仍然是一个挑战。本文讨论了利用各种生物大分子（包括抗体、核酸、蛋白质和肽、维生素、硫酸软骨素、透明质酸和乳糖酸）对白蛋白纳米颗粒进行功能化，从而实现对癌细胞的特异性识别和结合。此外，我们还强调了这种靶向方法在肿瘤特异性给药、最大限度地减少脱靶效应、潜在的疗效改善、细胞内化、减少副作用和更好的临床效果等方面的优越性。本综述的中心内容是它们如何彻底改变了生物医学研究领域，并调整为一种出色的靶向方法。总之，本综述详细强调了白蛋白作为一种纳米载体，以生物分子为配体进行肿瘤靶向递送的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AAPS PharmSciTech 医学-药学

CiteScore

6.80

自引率

3.00%

发文量

264

审稿时长

2.4 months

期刊介绍： AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.