The Minimally Invasive 1-Hr Esophageal String Test (EST) Monitors Therapeutic Changes in Mucosal Inflammation in Eosinophilic Esophagitis.

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2024-11-06 DOI:10.14309/ajg.0000000000003192

Steven J Ackerman, Amir F Kagalwalla, Zhaoxing Pan, Joshua Wechsler, Kaitlin Keeley, Nirmala Gonsalves, Ikuo Hirano, Angelika Zalewski, Paul Menard-Katcher, Calies Menard-Katcher, Sandeep K Gupta, Nikhil Chauhan, Milica Grozdanovic, Dan Atkins, Nathalie Nguyen, Glenn T Furuta

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引用次数: 0

Abstract

Background: Endoscopy, standard-of-care for monitoring Eosinophilic Esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST®), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment.

Methods: Thirty-three samples from 14 EoE patients (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs analyzed for EoEScores.

Results: Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.

Conclusion: The EST can be used to longitudinally monitor responses to treatment in EoE.

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微创 1 小时食管弦试验 (EST) 可监测嗜酸性粒细胞食管炎患者黏膜炎症的治疗变化。

背景：内窥镜检查是监测嗜酸性粒细胞食管炎（EoE）的标准方法，可评估粘膜炎症。食管弦试验（EST®）是一种微创吞咽胶囊和免疫测定，可量化嗜酸性粒细胞食管炎的炎症。我们确定EST/EoEScore能否监测正在接受治疗的患者的病情：研究了来自 14 名咽喉炎患者（7 名儿童，7 名成人）的 33 份样本，这些患者接受了重复内窥镜检查和EST。对活检样本进行嗜酸性粒细胞峰值计数分析；对EST进行嗜酸性粒细胞评分分析：结果：在治疗过程中，嗜酸性粒细胞计数和嗜酸性粒细胞分布指数有明显的相关性，93.9%的EST可将活动性咽喉炎患者与治疗相关缓解患者区分开来：EST可用于纵向监测咽喉炎患者的治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.