Impacts of Helicobacter pylori infection and eradication on gastrointestinal microbiota: An up-to-date critical review and future perspectives.

IF 7.5 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Yu Li, Cong He, Nonghua Lu
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引用次数: 0

Abstract

Abstract: Helicobacter pylori (H. pylori) infects approximately half of the population worldwide and causes chronic gastritis, peptic ulcers, and gastric cancer. Test-and-treat strategies have been recommended for the prevention of H. pylori-associated diseases. Advancements in high-throughput sequencing technologies have broadened our understanding of the complex gastrointestinal (GI) microbiota and its role in maintaining host homeostasis. Recently, an increasing number of studies have indicated that the colonization of H. pylori induces dramatic alterations in the gastric microbiota, with a predominance of H. pylori and a reduction in microbial diversity. Dysbiosis of the gut microbiome has also been observed after H. pylori infection, which may play a role in the development of colorectal cancer. However, there is concern regarding the impact of antibiotics on the gut microbiota during H. pylori eradication. In this review, we summarize the current literature concerning how H. pylori infection reshapes the GI microbiota and the underlying mechanisms, including changes in the gastric environment, immune responses, and persistent inflammation. Additionally, the impacts of H. pylori eradication on GI microbial homeostasis and the use of probiotics as adjuvant therapy are also discussed. The shifts in the GI microbiota and their crosstalk with H. pylori may provide potential targets for H. pylori-related gastric diseases and extragastric manifestations.

幽门螺杆菌感染和根除对胃肠道微生物群的影响:最新评论和未来展望。
摘要:幽门螺杆菌(H. pylori)感染了全球约一半的人口,并导致慢性胃炎、消化性溃疡和胃癌。为预防与幽门螺杆菌相关的疾病,人们推荐了检测和治疗策略。高通量测序技术的进步拓宽了我们对复杂的胃肠道(GI)微生物群及其在维持宿主体内平衡方面作用的认识。最近,越来越多的研究表明,幽门螺杆菌的定植会导致胃微生物群发生巨大变化,幽门螺杆菌占据主导地位,微生物多样性减少。幽门螺杆菌感染后,肠道微生物组也出现了菌群失调,这可能在结肠直肠癌的发病中起到一定作用。然而,在根除幽门螺杆菌的过程中,抗生素对肠道微生物群的影响令人担忧。在这篇综述中,我们总结了目前有关幽门螺杆菌感染如何重塑胃肠道微生物群及其潜在机制(包括胃环境变化、免疫反应和持续炎症)的文献。此外,我们还讨论了根除幽门螺杆菌对消化道微生物平衡的影响,以及使用益生菌作为辅助疗法。消化道微生物群的变化及其与幽门螺杆菌的相互影响可能为幽门螺杆菌相关胃病和胃外表现提供潜在的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chinese Medical Journal
Chinese Medical Journal 医学-医学:内科
CiteScore
9.80
自引率
4.90%
发文量
19245
审稿时长
6 months
期刊介绍: The Chinese Medical Journal (CMJ) is published semimonthly in English by the Chinese Medical Association, and is a peer reviewed general medical journal for all doctors, researchers, and health workers regardless of their medical specialty or type of employment. Established in 1887, it is the oldest medical periodical in China and is distributed worldwide. The journal functions as a window into China’s medical sciences and reflects the advances and progress in China’s medical sciences and technology. It serves the objective of international academic exchange. The journal includes Original Articles, Editorial, Review Articles, Medical Progress, Brief Reports, Case Reports, Viewpoint, Clinical Exchange, Letter,and News,etc. CMJ is abstracted or indexed in many databases including Biological Abstracts, Chemical Abstracts, Index Medicus/Medline, Science Citation Index (SCI), Current Contents, Cancerlit, Health Plan & Administration, Embase, Social Scisearch, Aidsline, Toxline, Biocommercial Abstracts, Arts and Humanities Search, Nuclear Science Abstracts, Water Resources Abstracts, Cab Abstracts, Occupation Safety & Health, etc. In 2007, the impact factor of the journal by SCI is 0.636, and the total citation is 2315.
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