Extraction of methamphetamine and pseudoephedrine by modified graphene oxide solid phase extraction method coupled to HPLC-UV in urine sample

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

BMC Chemistry Pub Date : 2024-11-05 DOI:10.1186/s13065-024-01331-y

Nasim Nourani, Yousef Javadzadeh, Ali Shayanfar, Arezou Taghvimi, Ahad Bavili-Tabrizi, Siavoush Dastmalchi

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Abstract

Methamphetamine, pseudoephedrine, and related drugs are among the first drugs used for the stimulation of the central nervous system. In this study, two adsorbents based on graphene oxide (GO) were synthesized and used for the analysis of methamphetamine and pseudoephedrine. The prepared nano-adsorbents based on GO in this study were coated by polyaniline (PANI) and Fe₃O₄/C-nanodot/GO (magnetic adsorbent). The average size of nanoparticles (GO/PANI) was 18.43 nm. The specific surface area and pore size diameter of Fe₃O₄/C-nanodot/GO were 22.71 m² g^− 1 and 15.23 nm, respectively. Experimental variables affecting the extraction efficiency of the analytes such as pH of the sample solution, amount of adsorbent, extraction time, and type of eluents were investigated and optimized by response surface methodology. Under optimum conditions, GO/PANI and Fe₃O₄/C-nanodot/GO were considered appropriate solid phase extraction adsorbents for HPLC-based analyses of the studied drugs in human urine samples. However, GO/Fe₃O₄ nano adsorbent (Fe₃O₄/C-nanodot/GO) showed superior working condition than GO/PANI. The validated proposed analytical methods can be used for the quantitative determination of methamphetamine and pseudoephedrine in actual samples.

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尿样中甲基苯丙胺和伪麻黄碱的改良氧化石墨烯固相萃取-高效液相色谱-紫外检测法

甲基苯丙胺、伪麻黄碱及相关药物是最早用于刺激中枢神经系统的药物之一。本研究合成了两种基于氧化石墨烯（GO）的吸附剂，并将其用于甲基苯丙胺和伪麻黄碱的分析。本研究中制备的基于 GO 的纳米吸附剂被聚苯胺（PANI）和 Fe3O4/C-nanodot/GO （磁性吸附剂）包覆。纳米颗粒（GO/PANI）的平均粒径为 18.43 nm。Fe3O4/C-nanodot/GO 的比表面积和孔径分别为 22.71 m2 g- 1 和 15.23 nm。采用响应面方法研究并优化了影响分析物萃取效率的实验变量，如样品溶液的 pH 值、吸附剂用量、萃取时间和洗脱液类型。在最佳条件下，GO/PANI 和 Fe3O4/C-nanodot/GO 被认为是基于 HPLC 分析人尿样中研究药物的合适固相萃取吸附剂。然而，GO/Fe3O4 纳米吸附剂（Fe3O4/C-nanodot/GO）的工作条件优于 GO/PANI。经过验证的拟议分析方法可用于实际样品中甲基苯丙胺和伪麻黄碱的定量检测。

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来源期刊

BMC Chemistry Chemistry-General Chemistry

CiteScore

5.30

自引率

2.20%

发文量

审稿时长

27 weeks

期刊介绍： BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.