A sympathetic paradigm shift for the role of NPY in obesity

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-11-05 DOI:10.1016/j.cmet.2024.10.010

Olivier Lavoie, Alexandre Caron

引用次数: 0

Abstract

Neuropeptide Y (NPY) is a powerful orexigenic factor in the brain. However, mice lacking NPY or NPY receptor Y1 (NPY1R) have minimal changes in basal food intake. In a study published in Nature, Zhu et al.¹ demystify this paradox and show that central and peripheral NPY have antipodal roles in energy homeostasis.

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NPY 在肥胖症中作用的同情范式转变

神经肽 Y（NPY）是大脑中一种强大的促食欲因子。然而，缺乏 NPY 或 NPY 受体 Y1（NPY1R）的小鼠，其基础食物摄入量变化极小。在发表于《自然》（Nature）的一项研究中，Zhu 等人1揭开了这一悖论的神秘面纱，并表明中枢和外周 NPY 在能量平衡中具有相反的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.