Mapping out multiple sclerosis with spatial transcriptomics

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-11-05 DOI:10.1038/s41593-024-01798-x

Kellie Horan, Anna C. Williams

引用次数: 0

Abstract

In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growing possibilities of spatial transcriptomics by applying it to the spatially heterogeneous disease multiple sclerosis. They validate the technique by comparison to classic pathology and reveal insights into demyelinated lesion markers, pathological cell types and lesion evolution.

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利用空间转录组学绘制多发性硬化症地图

在本期杂志中，Alsema、Wijering、Miedema、Kotah 等人和 Lerma-Martin、Badia-i-Mompel 等人将空间转录组学应用于空间异质性疾病多发性硬化症，从而展示了空间转录组学日益增长的可能性。他们通过与传统病理学的比较验证了这一技术，并揭示了脱髓鞘病变标志物、病理细胞类型和病变演变的深刻内涵。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.