Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2024-11-05 DOI:10.1016/j.jhazmat.2024.136401

Zi Ye, Leilei Yu, Dezhi Lu, Qingsong Zhang, Arjan Narbad, Wei Chen, Qixiao Zhai, Fengwei Tian

{"title":"Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis","authors":"Zi Ye, Leilei Yu, Dezhi Lu, Qingsong Zhang, Arjan Narbad, Wei Chen, Qixiao Zhai, Fengwei Tian","doi":"10.1016/j.jhazmat.2024.136401","DOIUrl":null,"url":null,"abstract":"Nonylphenol (NP), an endocrine-disrupting compound (EDC) with accumulative properties, poses significant risks to human health and the environment. The pivotal role of probiotics in mitigating EDC toxicity has garnered increasing attention. In this study, we assessed the protective effects of Bifidobacterium longum CCFM1077, a probiotic with outstanding in vitro NP-binding ability, against NP-induced toxicity in rats. This analysis revealed that B. longum CCFM1077 effectively promoted the NP excretion and enhanced intestinal barrier integrity. Interestingly, B. longum CCFM1077, by modulating the structure and the function of gut microbiota, increased the abundance of Turicibacter, significantly elevated the level of butyric acid, and upregulated antioxidant-related metabolic pathways, thereby alleviating brain inflammation and ultimately improving behavioral disorders. This study elucidated a strategy to alleviate NP toxicity and lays a theoretical foundation for the development of novel intestinal protection strategies. It supports environmental sustainability by offering a strategy to combat NP bioaccumulation, aligning with global initiatives to minimize the environmental impact of industrial pollutants.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":12.2000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hazardous Materials","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1016/j.jhazmat.2024.136401","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Nonylphenol (NP), an endocrine-disrupting compound (EDC) with accumulative properties, poses significant risks to human health and the environment. The pivotal role of probiotics in mitigating EDC toxicity has garnered increasing attention. In this study, we assessed the protective effects of Bifidobacterium longum CCFM1077, a probiotic with outstanding in vitro NP-binding ability, against NP-induced toxicity in rats. This analysis revealed that B. longum CCFM1077 effectively promoted the NP excretion and enhanced intestinal barrier integrity. Interestingly, B. longum CCFM1077, by modulating the structure and the function of gut microbiota, increased the abundance of Turicibacter, significantly elevated the level of butyric acid, and upregulated antioxidant-related metabolic pathways, thereby alleviating brain inflammation and ultimately improving behavioral disorders. This study elucidated a strategy to alleviate NP toxicity and lays a theoretical foundation for the development of novel intestinal protection strategies. It supports environmental sustainability by offering a strategy to combat NP bioaccumulation, aligning with global initiatives to minimize the environmental impact of industrial pollutants.

Abstract Image

查看原文本刊更多论文

长双歧杆菌 CCFM1077 对壬基酚毒性的缓解作用：体外和体内综合分析

壬基酚（NP）是一种具有累积特性的内分泌干扰化合物（EDC），对人类健康和环境构成重大风险。益生菌在减轻 EDC 毒性方面的关键作用日益受到关注。在本研究中，我们评估了具有出色的体外 NP 结合能力的益生菌长双歧杆菌 CCFM1077 对 NP 诱导的大鼠毒性的保护作用。分析表明，长双歧杆菌 CCFM1077 能有效促进 NP 的排泄，并增强肠道屏障的完整性。有趣的是，B. longum CCFM1077通过调节肠道微生物群的结构和功能，增加了Toricibacter的丰度，显著提高了丁酸的水平，并上调了抗氧化相关的代谢途径，从而缓解了脑部炎症，最终改善了行为障碍。这项研究阐明了一种减轻氮氧化物毒性的策略，并为开发新型肠道保护策略奠定了理论基础。它提供了一种对抗 NP 生物蓄积的策略，从而支持了环境的可持续发展，与最大限度减少工业污染物对环境影响的全球倡议相一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.