Surfactant-modified carbon nano-onion-β-cyclodextrin nanocomposite as an efficient sorbent in dispersive solid phase extraction of metoprolol and atenolol from plasma samples prior to HPLC–PDA analysis

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Zahra Aslanabadi, Mohammad Reza Afshar Mogaddam, Faranak Ghaderi, Elnaz Marzi Khosrowshahi, Aysa Abasalizadeh, Mir Ali Farajzadeh, Mahboob Nemati
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Abstract

In the present study, a modified carbon nano-onion and β–cyclodextrin composite was utilized in micro-solid phase extraction of atenolol and metoprolol from human plasma samples. The synthesized sorbent structure and morphology were evaluated. In this method, a proper amount of the sorbent was contacted with the diluted plasma sample under vortexing (to promote the sorbent contact area with the solution). The separated particles by centrifugation were contacted with a proper eluent to desorb the target analytes. After that, the eluent was separated by centrifugation and used during analysis of the analytes by high-performance liquid chromatograph. Several effective extraction parameters such as the sorbent amount, type and elution solvent volume, and extraction time were evaluated and optimized. The validated factors showed that detection and quantification were 0.09 and 0.01 and 0.29 and 0.03 ng mL–1, for metoprolol and atenolol, respectively. The method precision, considered as relative standard deviation, was ≤ 2.5 and ≤ 3.6% for intra- (n = 5) and inter-day (n = 4) precisions, respectively. The extraction recovery values were obtained 84 and 63% for metoprolol and atenolol, respectively. Lastly, the developed method was utilized successfully on the plasma samples of patients treated with metoprolol and atenolol.

表面活性剂修饰的纳米碳离子-β-环糊精纳米复合材料作为一种高效吸附剂,用于在 HPLC-PDA 分析前从血浆样品中分散固相萃取美托洛尔和阿替洛尔
本研究利用改性纳米碳离子和β-环糊精复合材料对人血浆样品中的阿替洛尔和美托洛尔进行微固相萃取。对合成的吸附剂结构和形态进行了评估。在该方法中,适量的吸附剂在涡旋状态下与稀释的血浆样品接触(以增加吸附剂与溶液的接触面积)。离心分离出的颗粒与适当的洗脱液接触,以解吸目标分析物。然后,通过离心分离洗脱液,并在使用高效液相色谱仪分析分析物时使用。评估并优化了几个有效的萃取参数,如吸附剂用量、类型和洗脱溶剂量以及萃取时间。结果表明,美托洛尔和阿替洛尔的检出限和定量限分别为 0.09 和 0.01 ng mL-1 及 0.29 和 0.03 ng mL-1。方法的精密度为相对标准偏差,日内精密度(n = 5)和日间精密度(n = 4)分别为≤2.5%和≤3.6%。美托洛尔和阿替洛尔的提取回收率分别为 84% 和 63%。最后,该方法成功地应用于美托洛尔和阿替洛尔治疗患者的血浆样品中。
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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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