Ultrasensitive and simultaneous detection for bioactive compounds of baicalein and chrysin in traditional Chinese medicine via Bi2MoO6-MWCNTs based sensing platform

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2024-11-05 DOI:10.1007/s42114-024-01003-4

Youwei Jiang, Yingyu Sima, Taghrid S. Alomar, Najla AlMasoud, Zeinhom M. El-Bahy, Jinxia Feng, Kun Wan, Zhexenbek Toktarbay, Quanguo He, Jianhua Ding, Jingfeng Wang, Wu Wang

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Abstract

The pursuit of rapid and sensitive detection methods for bioactive compounds in traditional Chinese medicine (TCM) is a continuous quest in the field of natural product chemistry. Herein, we report the development of a novel nanocomposite material comprising bismuth molybdate (Bi₂MoO₆) and multi-walled carbon nanotubes (MWCNTs), which has been successfully applied to the ultrasensitive and simultaneous detection of the bioactive flavonoids baicalein and chrysin. These compounds, known for their potent anticancer and antioxidant properties, are prevalent in TCM and nutraceuticals. The Bi₂MoO₆-MWCNTs nanocomposite was meticulously characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV), revealing its structural and functional attributes. The optimized electrochemical sensor, based on a glassy carbon electrode modified with the nanocomposite, demonstrated remarkable sensitivity with a linear response range of 0.001–5.0 μmol·L⁻¹ for baicalein and 0.007–3.0 μmol·L⁻¹ for chrysin, alongside impressively low detection limits of 0.2 nmol·L⁻¹ and 1.4 nmol·L⁻¹, respectively. The sensor’s performance was further validated through its application in the analysis of human serum and Scutellaria baicalensis extracts, showcasing its robust repeatability, selectivity, and stability. This work not only advances the field of TCM analysis but also opens new horizons for the integration of hollow bimetallic oxides with carbon-based materials in electrochemical sensing, offering a strategic approach to the rapid assessment of bioactive constituents in complex matrices.

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通过基于 Bi2MoO6-MWCNTs 的传感平台超灵敏地同时检测中药中的生物活性化合物黄芩苷和菊黄苷

天然产物化学领域一直在寻求快速灵敏的中药生物活性化合物检测方法。在此，我们报告了由钼酸铋（Bi2MoO6）和多壁碳纳米管（MWCNTs）组成的新型纳米复合材料的开发情况，该材料已成功应用于生物活性黄酮类化合物黄芩苷和菊黄苷的超灵敏同步检测。这些化合物以其强大的抗癌和抗氧化特性而闻名，在中药和营养保健品中十分普遍。利用 X 射线衍射 (XRD)、扫描电子显微镜 (SEM)、电化学阻抗光谱 (EIS) 和循环伏安法 (CV) 对 Bi2MoO6-MWCNTs 纳米复合材料进行了细致的表征，揭示了其结构和功能属性。优化后的电化学传感器以纳米复合材料修饰的玻璃碳电极为基础，灵敏度极高，黄芩苷的线性响应范围为 0.001-5.0 μmol-L-1，黄菊素的线性响应范围为 0.007-3.0 μmol-L-1，检出限分别为 0.2 nmol-L-1 和 1.4 nmol-L-1。该传感器的性能通过在人血清和黄芩提取物分析中的应用得到了进一步验证，展示了其强大的重复性、选择性和稳定性。这项工作不仅推动了中药分析领域的发展，还为中空双金属氧化物与碳基材料在电化学传感中的整合开辟了新天地，为快速评估复杂基质中的生物活性成分提供了一种战略性方法。

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.