The versatility of apigenin: Especially as a chemopreventive agent for cancer

Abstract

Apigenin, a naturally occurring flavonoid found in fruits and vegetables, has received substantial attention due to its various pharmacological effects, particularly in cancer therapy. This review delves deeply into apigenin's phytochemical properties and pharmacological activity, with a particular emphasis on its potential as a targeted cancer therapy. We conducted an exhaustive literature study to investigate the molecular processes underlying apigenin's anticancer actions, such as its ability to induce apoptosis, block angiogenesis, and decrease metastasis. We also examine its synergistic effects with conventional chemotherapy drugs and its potential as an adjuvant therapy. Furthermore, the paper discusses current advances in nanoparticle-based delivery systems that improve the bioavailability and efficacy of apigenin in cancer treatment. This detailed investigation aims to provide insights into apigenin's therapeutic capabilities and future possibilities in targeted cancer treatment.