Experimental study on the effect of Mongolian medicine warming acupuncture on proBDNF-tPA-BDNF balance in depression rats based on thermal imaging monitoring

IF 5.1 3区工程技术 Q2 ENERGY & FUELS

Thermal Science and Engineering Progress Pub Date : 2024-11-02 DOI:10.1016/j.tsep.2024.103030

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Abstract

Depression is a kind of mental illness affecting the whole world. Its pathological mechanism is complex, involving neurobiological and psychosocial factors.The depression model rats were randomly divided into control group, warm acupuncture group and drug treatment group. In order to evaluate the local thermal effect of warm acupuncture and moxibustion, real-time temperature changes of rat forebrain were monitored by thermal imaging technology. After the experiment, immunohistochemistry and Western blot were used to detect the expression levels of tPA and BDNF in the forebrain of each group of rats, and the relationship between tPA and BDNF was analyzed. The results of thermal imaging monitoring showed that local forebrain temperature in warm acupuncture group was significantly increased compared with control group (p < 0.05). The ratio of tPA to BDNF was significantly improved in the warm acupuncture and moxibustion group, suggesting that warm acupuncture and moxibustion can effectively regulate the balance of TPA-BDNF. The experimental results based on thermal imaging monitoring suggest that warm acupuncture can improve the balance of TPA-BDNF in the forebrain of depressed rats by promoting the expression of BDNF and tPA in the forebrain, which may provide a new method and mechanism basis for the treatment of depression.

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基于热成像监测的蒙药温针灸对抑郁大鼠proBDNF-tPA-BDNF平衡影响的实验研究

抑郁症是一种影响全世界的精神疾病，其病理机制复杂，涉及神经生物学和社会心理因素。抑郁症模型大鼠随机分为对照组、温针组和药物治疗组。为评价温针灸的局部热效应，采用热成像技术实时监测大鼠前脑的温度变化。实验结束后，采用免疫组化和 Western 印迹法检测各组大鼠前脑中 tPA 和 BDNF 的表达水平，并分析 tPA 和 BDNF 的关系。热成像监测结果显示，与对照组相比，温针灸组大鼠前脑局部温度明显升高（p <0.05）。温针灸组 tPA 与 BDNF 的比值明显提高，提示温针灸能有效调节 TPA-BDNF 的平衡。基于热成像监测的实验结果表明，温针灸可以通过促进大鼠前脑中BDNF和tPA的表达，改善抑郁大鼠前脑中TPA-BDNF的平衡，为抑郁症的治疗提供了新的方法和机制基础。

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来源期刊

Thermal Science and Engineering Progress Chemical Engineering-Fluid Flow and Transfer Processes

CiteScore

7.20

自引率

10.40%

发文量

327

审稿时长

41 days

期刊介绍： Thermal Science and Engineering Progress (TSEP) publishes original, high-quality research articles that span activities ranging from fundamental scientific research and discussion of the more controversial thermodynamic theories, to developments in thermal engineering that are in many instances examples of the way scientists and engineers are addressing the challenges facing a growing population – smart cities and global warming – maximising thermodynamic efficiencies and minimising all heat losses. It is intended that these will be of current relevance and interest to industry, academia and other practitioners. It is evident that many specialised journals in thermal and, to some extent, in fluid disciplines tend to focus on topics that can be classified as fundamental in nature, or are ‘applied’ and near-market. Thermal Science and Engineering Progress will bridge the gap between these two areas, allowing authors to make an easy choice, should they or a journal editor feel that their papers are ‘out of scope’ when considering other journals. The range of topics covered by Thermal Science and Engineering Progress addresses the rapid rate of development being made in thermal transfer processes as they affect traditional fields, and important growth in the topical research areas of aerospace, thermal biological and medical systems, electronics and nano-technologies, renewable energy systems, food production (including agriculture), and the need to minimise man-made thermal impacts on climate change. Review articles on appropriate topics for TSEP are encouraged, although until TSEP is fully established, these will be limited in number. Before submitting such articles, please contact one of the Editors, or a member of the Editorial Advisory Board with an outline of your proposal and your expertise in the area of your review.