Discovery of polyoxygenated briaranes from octocoral Briareum stechei

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-11-04 DOI:10.1016/j.phytol.2024.10.008

Yue-Wen Chuang , Wei-Chen Ting , Su-Ying Chien , Li-Guo Zheng , Chih-Yin Huang , Zhi-Hong Wen , Yu-Jen Wu , Junichi Tanaka , You-Ying Chen , Jui-Hsin Su , Ping-Jyun Sung

引用次数: 0

Abstract

A new 8,17-epoxybriarane, briastecholide O (1), was isolated from an encrusting algae-containing cultured octocoral Briareum stechei. Moreover, wild-type B. stechei collected from Okinawan waters yielded a new 8,17-epoxybriarane, briastecholide P (2), along with two known analogs, namely, briaexcavatins G (3) and X (4). Single-crystal X-ray diffraction was conducted to determine the absolute configurations of 2–4, while the structure of 1 was established by spectroscopic elucidation. Briaranes 1 and 3 were active in enhancing the growth of MG-63 human mesenchymal stem cells.

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从章鱼 Briareum stechei 中发现多氧烯酸萃取物

研究人员从一种含有结壳藻的养殖八目鳗 Briareum stechei 中分离出了一种新的 8,17-环氧三环烷，即 briastecholide O (1)。此外，从冲绳水域采集到的野生型 B. stechei 还产生了一种新的 8,17-环氧三环烷，即 briastecholide P (2)，以及两种已知的类似物，即 briaexcavatins G (3) 和 X (4)。通过单晶 X 射线衍射确定了 2-4 的绝对构型，而 1 的结构则是通过光谱分析确定的。布里阿兰 1 和 3 对促进 MG-63 人类间充质干细胞的生长具有活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.