A Biomimetic Nociceptor Based on a Vertical Multigate, Multichannel Neuromorphic Transistor

IF 15.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Han Xu, Da-Shan Shang*, Jianshi Tang*, Qing Luo, Xiaoxin Xu, Renrong Liang, Liyang Pan, Bin Gao, Qi Wang, Deyan He, Qi Liu*, Ming Liu, He Qian and Huaqiang Wu*, 
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Abstract

Nociceptors, crucial sensory receptors within biological systems, are essential for survival in diverse and potentially hazardous environments. Efforts to replicate nociceptors through advanced electronic devices, such as memristors and neuromorphic transistors, have achieved limited success, capturing basic nociceptive functions while more advanced characteristics like various forms of central sensitization and analgesic effect remain out of reach. Here, we introduce a vertical multigate, multichannel electrolyte-gated transistor (Vm-EGT), designed to mimic nociceptors. Utilizing the hybrid mechanism combining electric-double-layer (EDL) with ion intercalation/deintercalation in EGTs, our approach successfully replicates peripheral sensitization and desensitization characteristics of nociceptors. The intricate multigate and multichannel design of the Vm-EGT enables the emulation of more advanced nociceptive functionalities, including central sensitization and analgesic effect. Furthermore, we demonstrate that by exploiting the inherent current–voltage relationship, the Vm-EGT can simulate these advanced nociceptive features and seamlessly transition between them. Integrating a Vm-EGT with a thermistor and a heating plate, we have developed an artificial thermal nociceptor that closely mirrors the sensory attributes of its biological counterpart. Our approach significantly advances the emulation of nociceptors, providing a basis for the development of sophisticated artificial sensory systems and intelligent robotics.

Abstract Image

基于垂直多导多通道神经晶体管的仿生痛觉感受器
痛觉感受器是生物系统中至关重要的感觉受体,对于在各种潜在危险环境中生存至关重要。通过忆阻器和神经形态晶体管等先进电子器件复制痛觉感受器的努力只取得了有限的成功,只能捕捉到基本的痛觉功能,而像各种形式的中枢敏化和镇痛效果等更高级的特性仍无法实现。在这里,我们介绍一种垂直多导多通道电解质门控晶体管(Vm-EGT),旨在模拟痛觉感受器。利用电导晶体管中结合了电双层(EDL)和离子插层/脱插层的混合机制,我们的方法成功地复制了痛觉感受器的外周敏化和脱敏特性。Vm-EGT 复杂的多导和多通道设计能够模拟更高级的痛觉功能,包括中枢敏化和镇痛效果。此外,我们还证明,通过利用固有的电流-电压关系,Vm-EGT 可以模拟这些高级痛觉功能,并在它们之间无缝转换。我们将 Vm-EGT 与热敏电阻和加热板集成在一起,开发出了一种人工热痛觉感受器,它与生物对应物的感觉属性非常相似。我们的方法大大推进了痛觉感受器的仿真,为开发复杂的人工感觉系统和智能机器人奠定了基础。
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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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