Fat beyond muscle: Assessing epimuscular fat of the lumbar spine and its association with vertebral level, demographics, BMI, and low back pain.

IF 1.9 Q3 CLINICAL NEUROLOGY
Brain & spine Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.1016/j.bas.2024.103916
Jacopo A Vitale, Anne F Mannion, Daniel Haschtmann, Mario Ropelato, Tamás F Fekete, Frank S Kleinstück, Markus Loibl, Tina Haltiner, Fabio Galbusera
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Abstract

Introduction: Epimuscular fat (EF) has rarely been studied in the context of low back pain (LBP).

Research question: This study aims to assess the presence and extent of EF in the lumbar muscles and its association with vertebral level in patients with low back disorders and to explore correlations between EF, demographics, BMI, and LBP.

Material and methods: T2 axial MRIs from L1 to L5 were manually segmented to analyze the cross-sectional area (CSA) of EF (mm2), and fat infiltration (FI,%) of 40 patients (23 females, 17 males; mean age:65.9 years) with lumbar degenerative pathologies awaiting a surgical procedure. COMI, LBP, demographic, and clinical data were extracted from the institutional registry. Statistical analyses included Wilcoxon and Mann-Whitney tests for differences in EF between sides and sexes, the Friedman test for EF size differences among lumbar levels, and Spearman's correlation for associations, adjusted for BMI, age, and sex.

Results: EF was found in 77.5% of subjects at L1, 92.5% at L2, 100% at L3 and L4, and 95.0% at L5. EF was significantly larger at L4 (253.1 ± 183.6 mm2) and L5 (220.2 ± 194.9 mm2) than at L1 (36.1 ± 37.8 mm2) and L2 (72.2 ± 84.4 mm2). No significant EF differences were found between sides and sexes. EF correlated strongly with BMI (rs = 0.65,p < 0.001) and moderately with FI (rs = 0.31,p = 0.04), though its correlation with FI was not significant after adjustment. EF did not correlate with COMI scores but correlated with LBP in the adjusted analysis (rs:0.31,p = 0.04).

Discussion and conclusion: EF is present across all lumbar levels, with higher concentrations at L4 and L5, and a significant correlation between EF and LBP intensity was observed. The present findings are limited to a specific subset of patients with lumbar degenerative disorders who are awaiting surgical procedures.

肌肉之外的脂肪评估腰椎的肌肉外脂肪及其与脊椎水平、人口统计学、体重指数和腰痛的关系。
简介:关于腰背痛(LBP)的研究很少涉及肌肉外脂肪(EF):本研究旨在评估腰背疾病患者腰部肌肉中EF的存在和程度及其与脊椎水平的关系,并探讨EF、人口统计学、体重指数和腰背痛之间的相关性:对 40 名等待手术治疗的腰椎退行性病变患者(女性 23 人,男性 17 人;平均年龄:65.9 岁)的 L1 至 L5 的 T2 轴向 MRI 图像进行手动分割,以分析 EF 的横截面积(CSA)(mm2)和脂肪浸润(FI,%)。COMI、LBP、人口统计学和临床数据均从机构登记表中提取。统计分析包括Wilcoxon检验和Mann-Whitney检验,以检验两侧和性别间EF的差异;Friedman检验,以检验腰椎水平间EF大小的差异;Spearman相关性检验,以检验经BMI、年龄和性别调整后的相关性:77.5%的受试者在 L1 发现了 EF,92.5%在 L2,100%在 L3 和 L4,95.0%在 L5。L4(253.1 ± 183.6 mm2)和L5(220.2 ± 194.9 mm2)的EF明显大于L1(36.1 ± 37.8 mm2)和L2(72.2 ± 84.4 mm2)。不同侧面和性别的 EF 没有明显差异。EF与体重指数密切相关(rs = 0.65,p s = 0.31,p = 0.04),但经调整后,EF与FI的相关性并不显著。EF 与 COMI 评分没有相关性,但在调整分析中与 LBP 相关(rs:0.31,p = 0.04):EF存在于所有腰椎级别,在L4和L5级别浓度较高,EF与枸杞痛强度之间存在显著相关性。本研究结果仅限于等待手术治疗的特定腰椎退行性疾病患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain & spine
Brain & spine Surgery
CiteScore
1.10
自引率
0.00%
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审稿时长
71 days
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