Changes in anthropometry, adiposity, and inflammation in Black and White women engaged in intentional weight loss

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-11-04 DOI:10.1002/oby.24151

Ashley S. Felix, Jennifer A. Sinnott, Bette J. Caan, Shannon L. Gillespie, Caitlin E. Meade, Katherine E. Strafford, Casey M. Cosgrove, Loriana Soma, Sabrena Noria, Kristin L. Bixel, Ritu Salani, Christa I. Nagel, Laura M. Chambers, David E. Cohn, Adrian A. Suarez, Electra D. Paskett

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引用次数: 0

Abstract

Objective

We examined associations among changes in anthropometry, regional adiposity, and inflammatory markers in Black and White women participating in intentional weight loss.

Methods

A total of 104 women with BMI ≥ 25 kg/m² self-selected bariatric surgery (n = 66) or a diet and exercise program (n = 38). Anthropometric, dual-energy x-ray absorptiometry-quantified regional adiposity, and inflammatory markers (C-reactive protein [CRP], tumor necrosis factor α [TNF-α], soluble TNF receptor I [sTNFRI], sTNFRII, interleukin [IL]-6, and soluble IL-1 receptor antagonist) were measured at baseline and 6 months.

Results

Weight, BMI, visceral adipose tissue, and regional (android and gynoid) adiposity declined in the bariatric surgery group. Among bariatric surgery participants, Black women experienced declines of lesser magnitude in terms of weight and BMI than White women, but changes in regional adiposity and visceral adipose tissue did not differ. In the bariatric surgery group, decreases in weight and BMI were associated with decreases in CRP and IL-6 among White women, but not Black women. Decreases in weight, BMI, and android fat were associated with increases in TNF-α, sTNFRI, and sTNFRII among Black women, but not White women.

Conclusions

Decreases in anthropometry and adiposity were observed among Black and White bariatric surgery participants; however, associations among changes in adiposity, anthropometry, and inflammation differed by race.

Abstract Image

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有意减肥的黑人和白人女性在人体测量、脂肪和炎症方面的变化。

目的我们研究了参与有意减肥的黑人和白人女性的人体测量、区域脂肪含量和炎症指标变化之间的关联：共有 104 名体重指数≥ 25 kg/m2 的女性自主选择了减肥手术（66 人）或饮食和运动计划（38 人）。在基线和 6 个月时测量了人体测量指标、双能量 X 射线吸收测定法量化的区域脂肪含量和炎症指标（C 反应蛋白 [CRP]、肿瘤坏死因子 α [TNF-α]、可溶性 TNF 受体 I [sTNFRI]、sTNFRII、白细胞介素 [IL]-6 和可溶性 IL-1 受体拮抗剂）：结果：减肥手术组的体重、体重指数、内脏脂肪组织和区域（甲状腺和妇科）脂肪含量均有所下降。在减肥手术参与者中，黑人女性体重和体重指数的下降幅度小于白人女性，但区域脂肪含量和内脏脂肪组织的变化没有差异。在减肥手术组中，白人女性体重和体重指数的下降与 CRP 和 IL-6 的下降有关，但与黑人女性无关。黑人女性体重、体重指数和甲状腺脂肪的减少与 TNF-α、sTNFRI 和 sTNFRII 的增加有关，但与白人女性无关：结论：在黑人和白人减肥手术参与者中观察到人体测量和脂肪含量的减少；但是，脂肪含量、人体测量和炎症变化之间的关联因种族而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.