Thyroid Malignancies With Thymic Differentiation: Outcomes of Rare SETTLE and CASTLE Tumors.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-04 DOI:10.1002/hed.27969

Iulia Tapescu, Abigail Kohler, Neel R Sangal, Jason A Brant, Robert M Brody, Timothy Cao, Ryan M Carey

{"title":"Thyroid Malignancies With Thymic Differentiation: Outcomes of Rare SETTLE and CASTLE Tumors.","authors":"Iulia Tapescu, Abigail Kohler, Neel R Sangal, Jason A Brant, Robert M Brody, Timothy Cao, Ryan M Carey","doi":"10.1002/hed.27969","DOIUrl":null,"url":null,"abstract":"Background: Spindle epithelial tumors with thymus-like differentiation (SETTLE) and carcinomas showing thymus-like differentiation (CASTLE) are rare intrathyroid tumors.Methods: This retrospective cohort study included patients diagnosed with SETTLE, CASTLE, and papillary thyroid carcinoma (PTC) from 2004 to 2020 within the National Cancer Database (NCDB). Demographic, tumor, and treatment characteristics were compared. Overall survival (OS) was analyzed using the Kaplan-Meier method and Cox regression models.Results: This study identified 19 patients with CASTLE, 11 with SETTLE, and 483 474 with PTC. CASTLE and SETTLE patients had larger tumors, lymphovascular invasion, and positive surgical margins. They were rarely treated with radioactive iodine treatment but frequently received external beam radiation and chemotherapy. Five-year OS was significantly lower for CASTLE and SETTLE compared to PTC. SETTLE was associated with an increased risk of death.Conclusion: SETTLE and CASTLE are rare intrathyroid tumors with worse survival compared to PTC, often managed with radiation, chemotherapy, and surgery.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.27969","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Spindle epithelial tumors with thymus-like differentiation (SETTLE) and carcinomas showing thymus-like differentiation (CASTLE) are rare intrathyroid tumors.

Methods: This retrospective cohort study included patients diagnosed with SETTLE, CASTLE, and papillary thyroid carcinoma (PTC) from 2004 to 2020 within the National Cancer Database (NCDB). Demographic, tumor, and treatment characteristics were compared. Overall survival (OS) was analyzed using the Kaplan-Meier method and Cox regression models.

Results: This study identified 19 patients with CASTLE, 11 with SETTLE, and 483 474 with PTC. CASTLE and SETTLE patients had larger tumors, lymphovascular invasion, and positive surgical margins. They were rarely treated with radioactive iodine treatment but frequently received external beam radiation and chemotherapy. Five-year OS was significantly lower for CASTLE and SETTLE compared to PTC. SETTLE was associated with an increased risk of death.

Conclusion: SETTLE and CASTLE are rare intrathyroid tumors with worse survival compared to PTC, often managed with radiation, chemotherapy, and surgery.

查看原文本刊更多论文

胸腺分化的甲状腺恶性肿瘤：罕见的 SETTLE 和 CASTLE 肿瘤的结果。

背景：具有胸腺样分化的纺锤形上皮肿瘤（SETTLE）和显示胸腺样分化的癌肿（CASTLE）是罕见的甲状腺内肿瘤：具有胸腺样分化的纺锤形上皮肿瘤（SETTLE）和显示胸腺样分化的癌肿（CASTLE）是罕见的甲状腺内肿瘤：这项回顾性队列研究纳入了国家癌症数据库（NCDB）中2004年至2020年期间确诊的SETTLE、CASTLE和甲状腺乳头状癌（PTC）患者。研究人员比较了患者的人口统计学特征、肿瘤特征和治疗特征。采用Kaplan-Meier法和Cox回归模型对总生存期（OS）进行了分析：这项研究发现了 19 名 CASTLE 患者、11 名 SETTLE 患者和 483 474 名 PTC 患者。CASTLE和SETTLE患者肿瘤较大，淋巴管受侵，手术切缘阳性。他们很少接受放射性碘治疗，但经常接受体外放射治疗和化疗。与PTC相比，CASTLE和SETTLE的五年生存率明显较低。SETTLE与死亡风险增加有关：SETTLE和CASTLE是罕见的甲状腺内肿瘤，与PTC相比生存率更低，通常采用放疗、化疗和手术治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.