MicroRNAs in Aseptic Loosening of Prosthesis: Pathophysiology and Potential Therapeutic Approaches.

IF 1.2 Q3 ORTHOPEDICS

Archives of Bone and Joint Surgery-ABJS Pub Date : 2024-01-01 DOI:10.22038/ABJS.2024.70918.3319

Reza Minaei Noshahr, Farzad Amouzadeh Omrani, Atefeh Yadollahzadeh Chari, Mohammad Salehpour Roudsari, Firoozeh Madadi, Saman Shakeri Jousheghan, Alireza Manafi-Rasi

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引用次数: 0

Abstract

Objectives: Aseptic loosening (AL) is one of the leading causes of total joint arthroplasty (TJA) revision. Discovering the roles of microRNAs (miRNA/miR) in ontogenesis and osteolysis has attracted more attention to diagnosing and treating bone disorders. This review aimed to summarize miRNA biogenesis and describe the involvement of miRNAs in AL of implants.

Methods: A detailed search was carried out on scientific search engines, including Google Scholar, Web of Science, and PubMed, to find appropriate papers related to subjects. The search process was performed using the following keywords: "Implant", "miRNAs", "Wear particles", "Osteoclasts", "Total joint replacement", and "Osteolytic diseases".

Results: miRNAs play an essential role in the regulation of gene expression. AL is associated with several pathologic properties, including wear particle-induced persistent inflammatory response, unbalanced osteoclastogenesis, abnormal osteoblast differentiation, and maturation. Recent researches have revealed that these pathological events are closely associated with miRNA deregulation, confirming the relationship between miRNA and AL of prostheses.

Conclusion: With the results of the new approaches to target miRNA, the essential role of miRNA is further defined. Understanding the mechanisms of miRNAs and related signaling pathways in the pathophysiology of AL will help scientists illuminate novel therapeutic strategies and specific targeted drugs.

查看原文本刊更多论文

假体无菌性松动中的微RNA：病理生理学与潜在治疗方法》。

目的：无菌性松动（AL）是全关节成形术（TJA）翻修的主要原因之一。发现微小核糖核酸（miRNA/miR）在本体发生和骨溶解中的作用已引起人们对骨病诊断和治疗的更多关注。本综述旨在总结 miRNA 的生物发生过程，并描述 miRNA 在种植体 AL 中的参与情况：在谷歌学术、科学网和 PubMed 等科学搜索引擎上进行了详细搜索，以找到与主题相关的适当论文。搜索过程中使用了以下关键词："结果：miRNA 在基因表达调控中发挥着重要作用。AL 与多种病理特性有关，包括磨损颗粒诱导的持续性炎症反应、破骨细胞生成失衡、成骨细胞分化和成熟异常。最近的研究发现，这些病理事件与 miRNA 的失调密切相关，证实了 miRNA 与假体 AL 之间的关系：结论：随着针对 miRNA 的新方法取得成果，进一步明确了 miRNA 的重要作用。了解 miRNA 及相关信号通路在 AL 病理生理学中的作用机制，将有助于科学家阐明新的治疗策略和特异性靶向药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Bone and Joint Surgery-ABJS ORTHOPEDICS-

CiteScore

2.30

自引率

0.00%

发文量

128

期刊介绍： The Archives of Bone and Joint Surgery (ABJS) aims to encourage a better understanding of all aspects of Orthopedic Sciences. The journal accepts scientific papers including original research, review article, short communication, case report, and letter to the editor in all fields of bone, joint, musculoskeletal surgery and related researches. The Archives of Bone and Joint Surgery (ABJS) will publish papers in all aspects of today`s modern orthopedic sciences including: Arthroscopy, Arthroplasty, Sport Medicine, Reconstruction, Hand and Upper Extremity, Pediatric Orthopedics, Spine, Trauma, Foot and Ankle, Tumor, Joint Rheumatic Disease, Skeletal Imaging, Orthopedic Physical Therapy, Rehabilitation, Orthopedic Basic Sciences (Biomechanics, Biotechnology, Biomaterial..).