Longitudinal changes in choroidal thickness and choroidal vascularity index in age-related macular degeneration.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2024-11-04 DOI:10.1159/000541481

Lourdes Vidal-Oliver, Sabrina Spissinger, Elisa Herzig-de Almeida, Davide Garzone, Robert P Finger

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引用次数: 0

Abstract

Introduction: To investigate the rate of choroidal thinning and choroidal vascularity index (CVI) changes over time in eyes with different stages of age-related macular degeneration (AMD) and control eyes.

Methods: Retrospective longitudinal study of 105 eyes with different stages of AMD: non-advanced (n=46), exudative (n=28), central cRORA (n=5) and healthy eyes (n=26). We evaluated choroidal thickness (CT) and CVI at baseline and during 2-4 years of follow-up. After adjustment for age and sex, we estimated the rate of change per year of CT and CVI in each group. We also performed logistic regression to analyze the relationship between baseline CT and CVI with AMD progression.

Results: The mean age of the included patients was 77.1 years with a mean follow-up of 3.36 years. Healthy eyes had higher baseline CT and CVI values compared to eyes with AMD. Exudative AMD showed a significant annual decrease in subfoveal CT (-5.1% per year vs. -3.5% in controls) and in the temporal and nasal sectors (-5.3% and -6.3%). CVI decreased during follow-up in all study groups, most in eyes with central cRORA (-1.09% per year).

Conclusion: CVI and CT values are reduced in eyes with AMD compared to healthy eyes. Eyes with exudative AMD have the highest annual rate of choroidal thinning, while CVI decreases most in eyes with central cRORA. CT and CVI may aid in a further stratification of AMD progression risk.

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老年性黄斑变性患者脉络膜厚度和脉络膜血管指数的纵向变化。

简介：目的：研究不同阶段的老年性黄斑变性（AMD）患者和对照眼的脉络膜变薄率和脉络膜血管指数（CVI）随时间的变化：研究不同阶段年龄相关性黄斑变性（AMD）眼和对照眼的脉络膜变薄率和脉络膜血管指数（CVI）随时间的变化：回顾性纵向研究：对105只患有不同阶段AMD的眼睛进行研究：非晚期（46只）、渗出性（28只）、中央型cRORA（5只）和健康眼睛（26只）。我们对基线和 2-4 年随访期间的脉络膜厚度 (CT) 和 CVI 进行了评估。在对年龄和性别进行调整后，我们估算了每组中 CT 和 CVI 每年的变化率。我们还进行了逻辑回归分析基线 CT 和 CVI 与 AMD 进展之间的关系：研究对象的平均年龄为 77.1 岁，平均随访时间为 3.36 年。与 AMD 患者相比，健康眼的基线 CT 和 CVI 值更高。渗出性黄斑变性患者的眼底 CT（每年-5.1%，对照组为-3.5%）以及颞部和鼻部 CT（-5.3% 和-6.3%）每年都有显著下降。所有研究组的 CVI 在随访期间都有所下降，其中中央型 cRORA 患者的 CVI 降幅最大（每年-1.09%）：结论：与健康眼相比，AMD 患者的 CVI 和 CT 值均有所下降。结论：与健康眼相比，AMD 患者的 CVI 和 CT 值会降低，其中渗出性 AMD 患者的脉络膜变薄年增长率最高，而中心型 cRORA 患者的 CVI 降低幅度最大。CT 和 CVI 可能有助于对 AMD 进展风险进行进一步分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.