Pretreatment systemic immune-inflammation index and lymphocyte-to-monocyte ratio as prognostic factors in oral cavity cancer: A meta-analysis.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2024-11-01 DOI:10.1097/MD.0000000000040182

Jianghan Xu, Yanjun Lin, Jingbo Yang, Yifeng Xing, Xiaojie Xing

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引用次数: 0

Abstract

Background: The predictive implications of the pretreatment systemic immune-inflammation index (SII) and lymphocyte-to-monocyte ratio (LMR) in oral cavity cancer have been investigated extensively, however, the findings are conflicting.

Methods: To assess the predictive importance of SII and LMR in patients with oral cavity cancer, a comprehensive Meta-analysis of the literature was conducted using the databases from PubMed, Embase, and the Cochrane Library. To determine the link between SII and LMR and overall survival (OS) and disease-free survival (DFS), hazard ratio (HR) and 95% confidence interval (CI) were retrieved.

Results: The analysis comprised a total of 18 papers, covering 19 trials (SII = 5, LMR = 12, SII + prognostic nutritional index (PNI) = 2). According to pooled data, increased SII predicted poor OS (HR: 1.61, 95% CI: 1.38-1.87, P < .001) and DFS (HR: 1.90, 95% CI: 1.11-3.27, P = .02) while high LMR was linked with improved OS (HR: 0.64, 95% CI: 0.54-0.77, P < .001) and DFS (HR: 0.69, 95% CI: 0.61-0.79, P < .001). In addition, subgroup analysis indicated that high SII and low LMR negatively correlated with OS regardless of country, cutoff value, sample size, or types of Cox regression analysis.

Conclusions: High SII and low LMR may predict worse survival in patients with oral cavity cancer. SII and LMR may therefore represent effective indicators of prognosis in oral cavity cancer.

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作为口腔癌预后因素的治疗前全身免疫炎症指数和淋巴细胞与单核细胞比率：荟萃分析

背景：对口腔癌治疗前全身免疫炎症指数（SII）和淋巴细胞与单核细胞比值（LMR）的预测意义进行了广泛研究，但研究结果相互矛盾：为了评估 SII 和 LMR 在口腔癌患者中的预测重要性，我们使用 PubMed、Embase 和 Cochrane 图书馆的数据库对文献进行了全面的 Meta 分析。为了确定SII和LMR与总生存期（OS）和无病生存期（DFS）之间的联系，检索了危险比（HR）和95%置信区间（CI）：分析共包括 18 篇论文，涉及 19 项试验（SII = 5，LMR = 12，SII + 预后营养指数 (PNI) = 2）。根据汇总数据，SII的增加预示着较差的OS（HR：1.61，95% CI：1.38-1.87，P 结论：高 SII 和低 LMR 可能预示着口腔癌患者的生存率较低。因此，SII和LMR可能是口腔癌预后的有效指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

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