Lymphocyte subsets in pediatric acute lymphoblastic leukemia and their prognostic value.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2024-11-01 DOI:10.1097/MD.0000000000040342

Luyun Peng, Qingkai Dai, Yuefang Wang, Hao Yang, Rui Shi, Ge Zhang, Yongmei Jiang, Lei Ye

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引用次数: 0

Abstract

To study the changes of lymphocyte subsets in children with acute lymphoblastic leukemia (ALL) at initial diagnosis and compare them with those of healthy children and patients who have achieved complete remission (CR). Furthermore, we aim to analyze the prognostic significance of lymphocyte subsets in these patients. From May 2011 to December 2015, 405 children with ALL were enrolled in this study. Peripheral blood was collected at the time of diagnosis, and lymphocyte subsets were detected by flow cytometry. Then, the percentages of lymphocyte subsets in each group were compared. In addition, survival and prognostic factor analyses were performed to determine the prognostic value of lymphocyte subsets. Lymphocyte subsets in children with ALL were dramatically different from those in healthy children and patients achieving CR. Additionally, lymphocyte subsets were correlated with different minimal residual disease and risk parameters. Furthermore, percentages of CD3+ T cells and CD4+ T cells and the ratio of CD4/CD8 were associated with different clinical outcomes. Multivariate analysis demonstrated the percentage of CD4+ T cell as an independent predictor for clinical prognosis. Lymphocyte subsets in pediatric ALL undergo dramatic changes and were related to prognosis, especially CD4+ T cells.

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小儿急性淋巴细胞白血病的淋巴细胞亚群及其预后价值。

研究急性淋巴细胞白血病（ALL）患儿在初诊时淋巴细胞亚群的变化，并将其与健康儿童和获得完全缓解（CR）的患者进行比较。此外，我们还旨在分析淋巴细胞亚群在这些患者中的预后意义。2011年5月至2015年12月，405名ALL患儿参与了这项研究。在诊断时采集外周血，用流式细胞术检测淋巴细胞亚群。然后，比较各组淋巴细胞亚群的百分比。此外，还进行了存活率和预后因素分析，以确定淋巴细胞亚群的预后价值。ALL患儿的淋巴细胞亚群与健康儿童和获得CR的患者的淋巴细胞亚群有显著差异。此外，淋巴细胞亚群还与不同的最小残留病和风险参数相关。此外，CD3+ T细胞和CD4+ T细胞的百分比以及CD4/CD8的比率与不同的临床结果相关。多变量分析表明，CD4+ T细胞的百分比是临床预后的独立预测因子。小儿 ALL 中的淋巴细胞亚群发生了巨大变化，并与预后有关，尤其是 CD4+ T 细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.