Probiotic-based therapy as a new useful strategy for the treatment of patients with traumatic brain injury.

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES
Hanieh Asaadi, Abdolreza Narouiepour, Arezo Haji, Masoud Keikha, Mohsen Karbalaei
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引用次数: 0

Abstract

Background: In the new era, microbial-based medicine is one of the best strategies that try to modify the normal flora with the aim of treating some disorders. This systematic review and meta-analysis was performed to evaluate the use of probiotics in the treatment of the clinical outcomes in cases with traumatic brain injury..

Methods: In this regard, the search strategy was done using databases such as PubMed, Embase, Scopus, CENTRAL, and Google Scholar, from 2006 until April 2024. All studies about the efficacy of probiotic supplementation on the clinical outcomes in traumatic brain injury patients were retrieved. During the assessment process of the eligible studies, we evaluated clinical characteristics such as the Glasgow Coma Scale score, the Sequential Organ Failure Assessment score, the Acute Physiology and Chronic Health Evaluation II score, referral rate and hospitalization period in the intensive care unit, mortality rate, as well as opportunistic infections in both groups of case and control..

Results: In this study, the authors analyzed data from 6 articles including 391 cases with traumatic brain injury. Our results showed that the probiotic therapy increases the Glasgow Coma Scale score in patients with the average age of more than 50 years. However, there was no a significant difference in the Sequential Organ Failure Assessment and the Acute Physiology and Chronic Health Evaluation scores between the group that had received probiotics and the control group. Although probiotic-based treatment did not significantly affect the intensive care unit admission (or length of stay), but, the risk of infection, and also mortality was significantly lower in the probiotic group (OR: 0.53; 95% CI: 0.3 to 0.8, as well as OR: 0.41; 95% CI: 0.2 to 0.7, respectively)..

Conclusions: Overall, due to the modification of microbial flora, probiotic supplements can balance microflora disturbances, which in turn leads to improvement the clinical outcomes in patients with brain injury. Therefore, probiotic-based therapy can be considered as a promising strategy for the treatment of the central nervous system disorders. However, given the limited evidence, more clinical trial studies need to strengthen our results..

基于益生菌的疗法是治疗脑外伤患者的有效新策略。
背景:在新时代,以微生物为基础的医学是试图改变正常菌群以治疗某些疾病的最佳策略之一。本系统综述和荟萃分析旨在评估使用益生菌治疗脑外伤病例的临床效果:为此,研究人员利用 PubMed、Embase、Scopus、CENTRAL 和 Google Scholar 等数据库,对 2006 年至 2024 年 4 月期间的研究进行了检索。检索了所有关于补充益生菌对脑外伤患者临床疗效的研究。在对符合条件的研究进行评估的过程中,我们对病例组和对照组的临床特征进行了评估,如格拉斯哥昏迷量表评分、器官功能衰竭顺序评估评分、急性生理学和慢性健康评估 II 评分、转诊率和重症监护室住院时间、死亡率以及机会性感染等:在这项研究中,作者分析了来自 6 篇文章的数据,包括 391 例脑外伤病例。结果显示,益生菌疗法能提高平均年龄超过 50 岁的患者的格拉斯哥昏迷量表评分。然而,接受益生菌治疗组与对照组在序贯器官功能衰竭评估和急性生理学与慢性健康评估得分上没有明显差异。虽然益生菌治疗对重症监护室的入院率(或住院时间)没有明显影响,但益生菌组的感染风险和死亡率明显降低(OR:0.53;95% CI:0.3-0.8;OR:0.41;95% CI:0.2-0.7):总之,由于益生菌能改变微生物菌群,因此益生菌补充剂能平衡微生物菌群紊乱,进而改善脑损伤患者的临床疗效。因此,以益生菌为基础的疗法可被视为治疗中枢神经系统疾病的一种前景广阔的策略。然而,由于证据有限,我们需要更多的临床试验研究来加强我们的研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Infectious Diseases
BMC Infectious Diseases 医学-传染病学
CiteScore
6.50
自引率
0.00%
发文量
860
审稿时长
3.3 months
期刊介绍: BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
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