In-depth hemodynamic assessment in acute mild stroke patients with large vessel occlusion or stenosis.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2024-11-04 DOI:10.1186/s12883-024-03939-y

Ge Tian, Jing Huang, Jiajia Zhu, Qiheng Wu, Jia Yin

{"title":"In-depth hemodynamic assessment in acute mild stroke patients with large vessel occlusion or stenosis.","authors":"Ge Tian, Jing Huang, Jiajia Zhu, Qiheng Wu, Jia Yin","doi":"10.1186/s12883-024-03939-y","DOIUrl":null,"url":null,"abstract":"Objective: Acute treatment in mild stroke patients with acute anterior circulation large vessel occlusion/stenosis (AACLVO/S) had limited evidence. Hemodynamic play an important role in neurological deterioration. We aimed to investigate predictor value of hemodynamic assessment for clinical outcome predicting and guiding individual therapeutic decisions in those patients.Methods: We retrospectively analyze the stroke database in our stroke center. We recruited patients with mild stroke, defined by National Institutes of Health Stroke Scale (NIHSS) score ≤ 5, caused by AACLVO/S treated with just medical management (MT). They all received cerebral autoregulation (CA) assessments within 72 h after stroke onset. The primary end point was clinical outcome at 90-day after stroke.Results: Logistic regression analysis showed that bilateral higher baseline phase difference (PD) were independent variables related to favorable 90-day outcome, (OR 0.963, 95% CI 0.936-0.991, p = 0.040; OR 0.943, 95% CI 0.970-0.997; p = 0.008, respectively). The optimal cutoff value of bilateral PD was > 34.97º and > 14.29º respectively.Conclusion: CA evaluation can provide hemodynamic status in mild stroke patients with AACLVO/S.","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":"24 1","pages":"426"},"PeriodicalIF":2.2000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533346/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12883-024-03939-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Acute treatment in mild stroke patients with acute anterior circulation large vessel occlusion/stenosis (AACLVO/S) had limited evidence. Hemodynamic play an important role in neurological deterioration. We aimed to investigate predictor value of hemodynamic assessment for clinical outcome predicting and guiding individual therapeutic decisions in those patients.

Methods: We retrospectively analyze the stroke database in our stroke center. We recruited patients with mild stroke, defined by National Institutes of Health Stroke Scale (NIHSS) score ≤ 5, caused by AACLVO/S treated with just medical management (MT). They all received cerebral autoregulation (CA) assessments within 72 h after stroke onset. The primary end point was clinical outcome at 90-day after stroke.

Results: Logistic regression analysis showed that bilateral higher baseline phase difference (PD) were independent variables related to favorable 90-day outcome, (OR 0.963, 95% CI 0.936-0.991, p = 0.040; OR 0.943, 95% CI 0.970-0.997; p = 0.008, respectively). The optimal cutoff value of bilateral PD was > 34.97º and > 14.29º respectively.

Conclusion: CA evaluation can provide hemodynamic status in mild stroke patients with AACLVO/S.

查看原文本刊更多论文

对患有大血管闭塞或狭窄的急性轻度脑卒中患者进行深度血液动力学评估。

目的：对患有急性前循环大血管闭塞/狭窄（AACLVO/S）的轻度卒中患者进行急性治疗的证据有限。血液动力学在神经功能恶化中起着重要作用。我们的目的是研究血液动力学评估对预测这些患者的临床结果和指导个体治疗决策的预测价值：我们对卒中中心的卒中数据库进行了回顾性分析。我们招募了由 AACLVO/S 引起的轻度卒中患者，定义为美国国立卫生研究院卒中量表（NIHSS）评分≤ 5 分，仅接受内科治疗（MT）。他们都在卒中发生后 72 小时内接受了脑自动调节（CA）评估。主要终点是中风后90天的临床结果：逻辑回归分析显示，双侧较高的基线相位差（PD）是与 90 天良好预后相关的独立变量（OR 0.963，95% CI 0.936-0.991，p = 0.040；OR 0.943，95% CI 0.970-0.997；p = 0.008）。双侧 PD 的最佳临界值分别为 > 34.97º 和 > 14.29º：结论：CA 评估可提供 AACLVO/S 轻度卒中患者的血液动力学状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.