Prognosis of hepatitis B virus reactivation in newly diagnosed multiple myeloma in modern era therapy: a retrospective study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.7717/peerj.18475

Weiran Lv, Xiaojin Li, Jingbo Xu, Yun Wang, Hanying Huang, Fang Hu, Yingying Cui, Yuanbin Song, Lezong Chen, Bingyi Wu, Yang Liang

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Abstract

Studies on the prognosis of hepatitis B virus (HBV) reactivation following modern therapies for newly diagnosed MM (NDMM) are lacking. In this retrospective study, we aimed to assess the incidence, risk factors and prognosis of HBV reactivation in NDMM. A total of 33 of 355 patients with NDMM and HBV reactivation were included in this study. Multivariable analysis showed that hepatitis B surface antigen-positivity, hepatitis B core antibody-positivity, bortezomib-containing regimens, autologous stem cell transplantation, and gain of 1q21 were identified as independent risk factors of HBV reactivation in NDMM patients. The NDMM patients with HBV reactivation had poorer 3-year overall survival (OS) and progression-free survival (PFS) than did those without HBV reactivation, as confirmed by multivariate analysis. In conclusion, HBV reactivation in patients with NDMM constitutes a significant complication, correlating with reduced OS and PFS, and emerges as a potential adverse prognostic factor in the contemporary era of treatment.

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现代疗法中新近确诊的多发性骨髓瘤患者乙肝病毒再激活的预后：一项回顾性研究。

目前还缺乏对新诊断的 MM（NDMM）患者接受现代疗法后乙肝病毒（HBV）再活化预后的研究。在这项回顾性研究中，我们旨在评估NDMM中HBV再激活的发生率、风险因素和预后。本研究共纳入了355例NDMM患者中的33例HBV再激活患者。多变量分析显示，乙肝表面抗原阳性、乙肝核心抗体阳性、含硼替佐米方案、自体干细胞移植和1q21增益被确定为NDMM患者HBV再激活的独立危险因素。经多变量分析证实，与无HBV再激活的NDMM患者相比，有HBV再激活的NDMM患者的3年总生存期（OS）和无进展生存期（PFS）较差。总之，NDMM 患者的 HBV 再激活是一种重要的并发症，与 OS 和 PFS 的降低有关，是当代治疗中一个潜在的不良预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464