YB1 and its role in osteosarcoma: a review.

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.3389/fonc.2024.1452661

Feipeng Wu, Dapeng Li

引用次数: 0

Abstract

YB1 (Y box binding protein 1), a multifunctional protein capable of binding to DNA/RNA, is present in most cells and acts as a splicing factor. It is involved in numerous cellular processes such as transcription, translation, and DNA repair, significantly affecting cell proliferation, differentiation, and apoptosis. Abnormal expression of this protein is closely linked to the formation of various malignancies (osteosarcoma, nasopharyngeal carcinoma, breast cancer, etc.). This review examines the multifaceted functions of YB1 and its critical role in osteosarcoma progression, providing new perspectives for potential therapeutic strategies.

查看原文本刊更多论文

YB1 及其在骨肉瘤中的作用：综述。

YB1（Y 盒结合蛋白 1）是一种能够与 DNA/RNA 结合的多功能蛋白质，存在于大多数细胞中，是一种剪接因子。它参与许多细胞过程，如转录、翻译和 DNA 修复，对细胞增殖、分化和凋亡有重大影响。这种蛋白质的异常表达与各种恶性肿瘤（骨肉瘤、鼻咽癌、乳腺癌等）的形成密切相关。这篇综述探讨了 YB1 的多方面功能及其在骨肉瘤发展过程中的关键作用，为潜在的治疗策略提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.