Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.

IF 3.5 3区 医学 Q2 NEUROSCIENCES
Frontiers in Molecular Neuroscience Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.3389/fnmol.2024.1459858
Liqin Huang, Shangqi Sun, Gege Jiang, Guanfeng Xie, Yunying Yang, Sichun Chen, Jiaying Luo, Chen Lv, Xiang Li, Jianming Liao, Zhihao Wang, Zhaohui Zhang, Jing Xiong
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Abstract

Depression is one of the most common affective disorders in people's life. Women are susceptibility to depression during puberty, peripartum and menopause transition, when they are suffering from sex hormone fluctuation. A lot of studies have demonstrated the neuroprotective effect of estrogen on depression in women, however, the effect of FSH on depression is unclear. In this study, we investigated the role of FSH on depression in mice. Our study demonstrated that FSH induced depression-like behaviors in mice in a dose-dependent manner. This induction was associated with elevated levels of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α in both serum and hippocampal tissues. Additionally, FSH treatment resulted in impaired synaptic plasticity and a reduction in the expression of key synaptic proteins. It is noteworthy that the depression-like behaviors, inflammatory cytokines expression and synaptic plasticity impairment induced by FSH could be alleviated by knocking down the expression of FSH receptor (FSHR) in the hippocampus of the mice. Therefore, our findings reveal that FSH may play an important role in the pathogenesis of depression and targeting FSH may be a potential therapeutic strategy for depression during hormone fluctuation in women.

卵泡刺激素通过影响突触功能诱导抑郁样表型
抑郁症是人们生活中最常见的情感障碍之一。女性在青春期、围产期和更年期过渡时期,性激素波动较大,易患抑郁症。大量研究表明,雌激素对女性抑郁症有神经保护作用,但 FSH 对抑郁症的影响尚不明确。在这项研究中,我们调查了 FSH 对小鼠抑郁症的作用。我们的研究表明,前列腺素能以剂量依赖的方式诱导小鼠出现抑郁样行为。这种诱导与促炎细胞因子水平升高有关,包括血清和海马组织中的 IL-1β、IL-6 和 TNF-α。此外,FSH 治疗导致突触可塑性受损,关键突触蛋白的表达减少。值得注意的是,FSH诱导的抑郁样行为、炎性细胞因子表达和突触可塑性受损可以通过敲除小鼠海马中的FSH受体(FSHR)的表达来缓解。因此,我们的研究结果表明,FSH在抑郁症的发病机制中可能起着重要作用,针对FSH可能是女性激素波动期间抑郁症的一种潜在治疗策略。
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来源期刊
CiteScore
5.70
自引率
2.10%
发文量
669
审稿时长
14 weeks
期刊介绍: Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.
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