Positive association of the thigh muscle thickness to intracellular-water ratio with handgrip strength, but not with the risk of mortality in hospitalized cancer patients: a longitudinal study.
Tatyanne L N Gomes, Jessica F M Ivo, Lara G Mainardi, Gustavo D Pimentel
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Abstract
This study explored the relationship between handgrip strength, muscle thickness, and the intracellular water ratio (MT/ICW) in cancer patients. It aimed to identify a cut-off point for the MT/ICW ratio that might influence survival. Conducted as an exploratory, longitudinal study in a public hospital, it included patients from 2018 to 2022, with follow-up until August 31, 2023. The cut-off for the MT/ICW ratio was determined based on its sensitivity for mortality. Results indicated that patients with an MT/ICW ratio >0.97 had significantly lower extracellular water percentages and greater muscle thickness. A positive association was found between the MT/ICW ratio and handgrip strength, even after adjusting for age, sex, extracellular water, and body mass index. However, patients with an MT/ICW ratio ≤0.97 showed no significant mortality risk. In conclusion, MT/ICW ratio >0.97 mm/L in hospitalized cancer patients was positively associated with handgrip strength, but not risk of mortality.
期刊介绍:
The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion.
Topics of interest include but are not limited to:
Nutrition and Health (including climate and ecological aspects)
Metabolism & Metabolomics
Genomics and personalized strategies in nutrition
Nutrition during the early life cycle
Health issues and nutrition in the elderly
Phenotyping in clinical nutrition
Nutrition in acute and chronic diseases
The double burden of ''malnutrition'': Under-nutrition and Obesity
Prevention of Non Communicable Diseases (NCD)