Carbon dot-based nanomaterials with enzyme-like activity for fluorescence imaging and potential combination with therapy of cancer

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2024-11-04 DOI:10.1007/s00604-024-06813-3

Juan Ning, Guojie Li, Yijun Zhao, Jiahui Shi, Yamin Nie, Yonghong Li, Yanmei Zhou

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Abstract

Carbon dot-based nanomaterials (o-CDs@Mn) were fabricated by assembling fluorescent o-CDs with enzyme-like activity and Mn nanoparticles with photothermal properties for realizing fluorescence imaging and combined therapy of cancer. Due to the inherent optical properties of o-CDs, o-CDs@Mn can be effectively used for bioimaging. In addition, o-CDs@Mn possess peroxidase-like (POD-like) and glutathione (GSH) degradation capabilities, which can effectively deplete excessive H₂O₂ and GSH in the tumor microenvironment (TME), generating ·OH and reduced GSSH for regulating the TME and triggering ROS-mediated apoptosis in cancer cells. More importantly, it is synergistically supplemented with fluorescence imaging and photothermal therapy (PTT), which realizes the integration of monitoring and combined treatment, providing a promising potential pathway for accurate and efficient cancer treatment.

Graphical Abstract

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具有类似酶活性的碳点纳米材料，可用于荧光成像和潜在的癌症联合治疗。

通过将具有类酶活性的荧光 o-CDs 和具有光热特性的 Mn 纳米颗粒组装在一起，制备了基于碳点的纳米材料（o-CDs@Mn），用于实现荧光成像和癌症的联合治疗。由于 o-CDs 本身的光学特性，o-CDs@Mn 可以有效地用于生物成像。此外，o-CDs@Mn 还具有过氧化物酶样（POD-like）和谷胱甘肽（GSH）降解能力，可有效消耗肿瘤微环境（TME）中过量的 H2O2 和 GSH，产生 -OH 和还原型 GSSH，从而调节 TME，并引发 ROS 介导的癌细胞凋亡。更重要的是，它与荧光成像和光热疗法（PTT）协同互补，实现了监测与联合治疗的一体化，为准确、高效地治疗癌症提供了一条前景广阔的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.