Emerging role of endogenous peptides encoded by non-coding RNAs in cancer biology

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2024-10-28 DOI:10.1016/j.ncrna.2024.10.006

Anna Lucia Tornesello , Andrea Cerasuolo , Noemy Starita , Sara Amiranda , Tiziana Pecchillo Cimmino , Patrizia Bonelli , Franca Maria Tuccillo , Franco Maria Buonaguro , Luigi Buonaguro , Maria Lina Tornesello

{"title":"Emerging role of endogenous peptides encoded by non-coding RNAs in cancer biology","authors":"Anna Lucia Tornesello , Andrea Cerasuolo , Noemy Starita , Sara Amiranda , Tiziana Pecchillo Cimmino , Patrizia Bonelli , Franca Maria Tuccillo , Franco Maria Buonaguro , Luigi Buonaguro , Maria Lina Tornesello","doi":"10.1016/j.ncrna.2024.10.006","DOIUrl":null,"url":null,"abstract":"<div><div>Non-coding RNAs have long been recognized for their regulatory roles in various cellular processes, including cancer development and progression. Recent advancements have shed light on a novel aspect of non-coding RNA biology, revealing their ability to encode endogenous peptides also named micropeptides or microprotein through short open reading frames (sORFs). These small proteins play crucial roles in oncogenic processes, acting as either tumour suppressors or tumour promoters, and hold enormous potential as biomarkers for early diagnosis of cancer and as therapeutic targets. This comprehensive review highlights the state of the art on peptides encoded by long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), elucidating their regulatory functions and implications in different cancer types, including breast cancer, hepatocellular carcinoma and colorectal cancer. The review also discusses challenges and future directions in the exploration of these emerging players in cancer biology, emphasizing the importance of further investigation for their clinical translation in diagnosis and therapy.</div></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"10 ","pages":"Pages 231-241"},"PeriodicalIF":5.9000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Non-coding RNA Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468054024001495","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Non-coding RNAs have long been recognized for their regulatory roles in various cellular processes, including cancer development and progression. Recent advancements have shed light on a novel aspect of non-coding RNA biology, revealing their ability to encode endogenous peptides also named micropeptides or microprotein through short open reading frames (sORFs). These small proteins play crucial roles in oncogenic processes, acting as either tumour suppressors or tumour promoters, and hold enormous potential as biomarkers for early diagnosis of cancer and as therapeutic targets. This comprehensive review highlights the state of the art on peptides encoded by long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), elucidating their regulatory functions and implications in different cancer types, including breast cancer, hepatocellular carcinoma and colorectal cancer. The review also discusses challenges and future directions in the exploration of these emerging players in cancer biology, emphasizing the importance of further investigation for their clinical translation in diagnosis and therapy.

查看原文本刊更多论文

非编码 RNA 所编码的内源性肽在癌症生物学中的新作用

非编码 RNA 在各种细胞过程（包括癌症的发生和发展）中的调控作用早已得到公认。最近的研究进展揭示了非编码 RNA 生物学的一个新方面，即通过短开放阅读框（sORF）编码内源性肽（也称微肽或微蛋白）的能力。这些小蛋白在致癌过程中起着至关重要的作用，既可作为肿瘤抑制因子，也可作为肿瘤促进因子，作为癌症早期诊断的生物标志物和治疗靶点具有巨大的潜力。本综述重点介绍了长非编码 RNA（lncRNA）、microRNA（miRNA）和环状 RNA（circRNA）编码的肽的最新研究进展，阐明了它们在不同癌症类型（包括乳腺癌、肝细胞癌和结肠直肠癌）中的调控功能和影响。综述还讨论了探索这些癌症生物学新角色所面临的挑战和未来方向，强调了进一步研究它们在诊断和治疗中的临床应用的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.