Sweat-Enhanced Self-Adhesive Double-Network Hydrogel for Dynamic Skin Electrophysiology

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-10-03 DOI:10.1021/acsmaterialslett.4c0174810.1021/acsmaterialslett.4c01748

Huarun Liang, Mengjia Zhu, Shuo Li, Haomin Wang, Donghang Li, Xiaoping Liang, Haojie Lu, Xun-En Wu, Haoxuan Ma, Nan Liu and Yingying Zhang*,

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Abstract

Electrophysiological monitoring is essential in healthcare and life sciences, yet conventional Ag/AgCl electrodes face challenges such as interfacial instability and motion artifacts. Herein, we propose a sweat-enhanced electrode design with a double-network hydrogel, comprising Ca²⁺-modified silk fibroin (SF) and poly(acrylic acid) grafted with N-hydroxysuccinimide ester (PAA-NHS). The obtained biocomposite, SF-PAA-NHS (BioSP), exhibits strong skin adhesion through covalent cross-linking and intermolecular forces, achieving an interfacial toughness of 411 J m^–2. Upon sweating, SF enhances adhesion by strengthening molecular mobility and mechanical interlocking, resulting in a nearly 23% increase in interfacial toughness. Additionally, sweat electrolytes boost BioSP’s ionic conductivity by about 45%, enhancing its electrophysiological monitoring capabilities. BioSP can also be combined with elastomers for excellent antidrying performance. Finally, high-fidelity and long-duration electrophysiological measurements validate the superior performance of the sweat-enhanced electrode, representing a significant advancement in skin electrode technology for reliable and durable monitoring on dynamic and sweaty tissue.

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用于动态皮肤电生理学的汗液增强型自粘性双网水凝胶

电生理监测在医疗保健和生命科学领域至关重要，然而传统的银/氯化银电极面临着界面不稳定和运动伪影等挑战。在此，我们提出了一种汗液增强电极设计，该电极由 Ca2+ 改性丝纤维素（SF）和 N-羟基琥珀酰亚胺酯接枝的聚丙烯酸（PAA-NHS）组成的双网水凝胶。获得的生物复合材料 SF-PAA-NHS （BioSP）通过共价交联和分子间作用力表现出很强的皮肤粘附性，界面韧性达到 411 J m-2。出汗时，SF 通过加强分子流动性和机械互锁来增强粘附性，从而使界面韧性提高了近 23%。此外，汗液电解质还能将 BioSP 的离子电导率提高约 45%，从而增强其电生理监测能力。BioSP 还可与弹性体结合使用，具有出色的防干燥性能。最后，高保真和长时间的电生理测量验证了汗液增强电极的卓越性能，标志着皮肤电极技术在动态和多汗组织的可靠持久监测方面取得了重大进展。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.