Effect of antibiotic drug use on outcome and therapy-related toxicity in patients with glioblastoma-A retrospective cohort study.

IF 3.7 Q1 CLINICAL NEUROLOGY
Neuro-oncology advances Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI:10.1093/noajnl/vdae170
Linda Götz, Tananeh Ansafi, Michael Gerken, Monika Klinkhammer-Schalke, Anna Fischl, Markus J Riemenschneider, Martin Proescholdt, Elisabeth Bumes, Oliver Kölbl, Nils Ole Schmidt, Ralf Linker, Peter Hau, Tareq M Haedenkamp
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引用次数: 0

Abstract

Background: Glioblastoma (GB) is the most frequent malignant brain tumor and has a dismal prognosis. In other cancers, antibiotic use has been associated with severity of chemotherapy-induced toxicity and outcome. We investigated if these mechanisms are also involved in GB.

Methods: We selected a cohort of 78 GB patients who received combined radiochemotherapy. We investigated if exposure to prediagnostic antibiotic use is associated with clinical side effects and laboratory changes during adjuvant therapy as well as overall survival (OS) and progression-free survival (PFS) using chi-square test, binary logistic regression, Kaplan-Meyer analysis, and multivariable Cox regression.

Results: Seventeen patients (21.8%) received at least one course of prediagnostic antibiotics and 61 (78.2%) received no antibiotics. We found a higher incidence of loss of appetite (23.5% vs. 4.9%; P = .018) and myelosuppression (41.2% vs. 18.0%; P = .045) in the antibiotic group. Multivariable logistic regression analysis revealed antibiotics to be a predictor for nausea (OR = 6.94, 95% CI: 1.09-44.30; P = .041) and myelosuppression (OR = 9.75, 95% CI: 1.55-61.18; P = .015). Furthermore, lymphocytopenia was more frequent in the antibiotic group (90.0% vs. 56.1%, P = .033). There were no significant differences in OS (P = .404) and PFS (P = .844). Multivariable Cox regression showed a trend toward shorter survival time (P = .089) in the antibiotic group.

Conclusions: Our study suggests that antibiotic use affects symptoms and lab values in GB patients. Larger prospective studies are required to investigate if prediagnostic antibiotic use could be a prognostic factor in GB patients.

抗生素用药对胶质母细胞瘤患者预后和治疗相关毒性的影响--一项回顾性队列研究。
背景:胶质母细胞瘤(GB)是最常见的恶性脑肿瘤,预后极差。在其他癌症中,抗生素的使用与化疗引起的毒性和预后的严重程度有关。我们研究了这些机制是否也与脑胶质瘤有关:方法:我们选择了 78 例接受联合放化疗的 GB 患者。我们使用秩方检验、二元逻辑回归、Kaplan-Meyer分析和多变量Cox回归研究了诊断前使用抗生素是否与辅助治疗期间的临床副作用和实验室变化以及总生存期(OS)和无进展生存期(PFS)相关:17名患者(21.8%)接受了至少一个疗程的诊断前抗生素治疗,61名患者(78.2%)未接受抗生素治疗。我们发现抗生素组食欲不振(23.5% 对 4.9%;P = .018)和骨髓抑制(41.2% 对 18.0%;P = .045)的发生率更高。多变量逻辑回归分析显示,抗生素是恶心(OR = 6.94,95% CI:1.09-44.30;P = .041)和骨髓抑制(OR = 9.75,95% CI:1.55-61.18;P = .015)的预测因素。此外,抗生素组淋巴细胞减少的发生率更高(90.0% 对 56.1%,P = .033)。OS (P = .404) 和 PFS (P = .844) 无明显差异。多变量考克斯回归显示,抗生素组的生存时间有缩短的趋势(P = .089):我们的研究表明,抗生素的使用会影响 GB 患者的症状和化验值。结论:我们的研究表明,抗生素的使用会影响GB患者的症状和化验值,因此需要进行更大规模的前瞻性研究,以探讨诊断前使用抗生素是否会成为GB患者的预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
0.00%
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审稿时长
12 weeks
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