Impact of Paroxysmal Atrial Tachycardia on Thromboembolic Events and Major Adverse Cardiovascular Events: A Single-Center Retrospective Study.

IF 2.7 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Risk Management and Healthcare Policy Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.2147/RMHP.S482876

Peng Liu, Tingting Lv, Yuanwei Liu, Xiaofei Zhang, Fei She, Rong He, Dan Li, Lianfeng Liu, Ping Zhang

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引用次数: 0

Abstract

Objective: Atrial fibrillation (AF) is known to increase the risk of thromboembolic events and major adverse cardiovascular events (MACE). The impact of paroxysmal atrial tachycardia (PAT) on these risks remains unclear.

Methods: This retrospective cohort study was conducted involving 889 patients diagnosed with PAT and 1106 control patients without PAT, all of whom underwent their initial 24-hour ECG monitoring between 2015 to 2020. Kaplan-Meier survival analysis and Cox regression analysis were used to evaluate the association between PAT and the study endpoints, including thromboembolic events and MACE.

Results: Over a mean follow-up period of 50.3 months, the incidence of thromboembolic events and MACE was significantly higher in the PAT group compared to the control group (6.5% vs 1.7% and 19.1% vs 9.9%, respectively). After adjusting for common risk factors and baseline imbalances, the PAT group exhibited a significantly elevated risk of thromboembolic events (hazard ratio [HR] 3.782, 95% confidence interval [CI] 2.212-6.467; P <0.001) and MACE (HR 1.795, 95% CI 1.398-2.305; P <0.001). However, the frequency of PAT episodes, heart rate, and maximum heart rate were not significantly associated with these outcomes. Within the PAT group, a history of stroke, transient ischemic attack, and chronic renal failure were identified as independent risk factors for thromboembolic events, while hypertension, coronary heart disease, heart failure, and chronic renal failure were independently associated with MACE.

Conclusion: PAT, as detected by 24-hour dynamic ECG, is associated with an increased risk of thromboembolic events and MACE.

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阵发性房性心动过速对血栓栓塞事件和主要不良心血管事件的影响：单中心回顾性研究

目的：众所周知，心房颤动（AF）会增加血栓栓塞事件和主要不良心血管事件（MACE）的风险。阵发性房性心动过速（PAT）对这些风险的影响仍不清楚：这项回顾性队列研究涉及 889 名确诊为阵发性房性心动过速的患者和 1106 名无阵发性房性心动过速的对照组患者，他们都在 2015 年至 2020 年期间接受了首次 24 小时心电图监测。研究采用卡普兰-梅耶生存分析和考克斯回归分析来评估PAT与研究终点（包括血栓栓塞事件和MACE）之间的关联：在平均 50.3 个月的随访期内，PAT 组的血栓栓塞事件和 MACE 发生率明显高于对照组（分别为 6.5% 对 1.7% 和 19.1% 对 9.9%）。在对常见风险因素和基线失衡进行调整后，PAT 组发生血栓栓塞事件的风险明显升高（危险比 [HR] 3.782，95% 置信区间 [CI] 2.212-6.467; P P 结论：通过 24 小时动态心电图检测出的 PAT 与血栓栓塞事件和 MACE 风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Risk Management and Healthcare Policy Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.20

自引率

2.90%

发文量

242

审稿时长

16 weeks

期刊介绍： Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include: Public and community health Policy and law Preventative and predictive healthcare Risk and hazard management Epidemiology, detection and screening Lifestyle and diet modification Vaccination and disease transmission/modification programs Health and safety and occupational health Healthcare services provision Health literacy and education Advertising and promotion of health issues Health economic evaluations and resource management Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.