Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries.

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-10-25 DOI:10.1016/j.tig.2024.09.009

Lisette Payero, Eric Alani

引用次数: 0

Abstract

Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pair receiving at least one crossover. The association of crossovers with distal sister chromatid cohesion is critical for the proper segregation of homologs in the first meiotic division. Studies in baker's yeast (Saccharomyces cerevisiae) have shown that meiotic crossovers result primarily from the biased resolution of double Holliday junction (dHJ) recombination intermediates through the actions of factors that belong to the DNA mismatch repair family. These findings and studies involving fine-scale mapping of meiotic crossover events have led to a new generation of mechanistic models for crossing over that are currently being tested.

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减数分裂过程中同源染色体间的交叉重组：最新进展与未解之谜。

在大多数真核生物中，减数分裂中同源染色体之间的交叉对于产生具有正确倍性的配子至关重要。减数分裂中的交叉通常是均匀分布的，每对同源染色体至少有一次交叉。交叉点与远端姐妹染色单体的结合对于同源物在减数第一次分裂中的正确分离至关重要。对面包酵母（Saccharomyces cerevisiae）的研究表明，减数分裂交叉主要是通过 DNA 错配修复家族因子的作用，有偏差地解决双霍利迪连接（dHJ）重组中间产物而产生的。这些发现以及对减数分裂交叉事件进行精细绘图的研究，产生了新一代的交叉机理模型，目前正在对这些模型进行测试。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.